abnormal susceptibility to weight gain Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake (Mammalian Phenotype Ontology, MP_0011117)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011117
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Genes

194 gene mutations causing the abnormal susceptibility to weight gain phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A2M alpha-2-macroglobulin
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACOT11 acyl-CoA thioesterase 11
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADRA1B adrenoceptor alpha 1B
ADRB3 adrenoceptor beta 3
AEBP1 AE binding protein 1
AGTR2 angiotensin II receptor, type 2
AHNAK AHNAK nucleoprotein
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALMS1 Alstrom syndrome protein 1
APOC3 apolipoprotein C-III
APOE apolipoprotein E
ARID5B AT rich interactive domain 5B (MRF1-like)
ARRDC3 arrestin domain containing 3
ASIP agouti signaling protein
ATXN2 ataxin 2
BBS12 Bardet-Biedl syndrome 12
BBS4 Bardet-Biedl syndrome 4
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BCO1 beta-carotene oxygenase 1
BDNF brain-derived neurotrophic factor
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CARTPT CART prepropeptide
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC80 coiled-coil domain containing 80
CCL13 chemokine (C-C motif) ligand 13
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CELF4 CUGBP, Elav-like family member 4
CERS6 ceramide synthase 6
CIDEC cell death-inducing DFFA-like effector c
CLOCK clock circadian regulator
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CNOT3 CCR4-NOT transcription complex, subunit 3
CNR1 cannabinoid receptor 1 (brain)
COL1A1 collagen, type I, alpha 1
COL5A3 collagen, type V, alpha 3
CPT1C carnitine palmitoyltransferase 1C
CRBN cereblon
CREBBP CREB binding protein
CRTC3 CREB regulated transcription coactivator 3
CSPG4 chondroitin sulfate proteoglycan 4
CTF1 cardiotrophin 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DGAT1 diacylglycerol O-acyltransferase 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DRD3 dopamine receptor D3
DUSP1 dual specificity phosphatase 1
EPM2AIP1 EPM2A (laforin) interacting protein 1
ESRRA estrogen-related receptor alpha
FABP2 fatty acid binding protein 2, intestinal
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FFAR4 free fatty acid receptor 4
FOXO1 forkhead box O1
FOXS1 forkhead box S1
FTO fat mass and obesity associated
GALP galanin-like peptide
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDF3 growth differentiation factor 3
GHRHR growth hormone releasing hormone receptor
GHSR growth hormone secretagogue receptor
GPBAR1 G protein-coupled bile acid receptor 1
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPR21 G protein-coupled receptor 21
GPR26 G protein-coupled receptor 26
GPR50 G protein-coupled receptor 50
HADH hydroxyacyl-CoA dehydrogenase
HCRT hypocretin (orexin) neuropeptide precursor
HDC histidine decarboxylase
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HMGA2 high mobility group AT-hook 2
HRH3 histamine receptor H3
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL18 interleukin 18
IL1R1 interleukin 1 receptor, type I
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KDM3A lysine (K)-specific demethylase 3A
LCLAT1 lysocardiolipin acyltransferase 1
LDLR low density lipoprotein receptor
LEPR leptin receptor
LIPE lipase, hormone-sensitive
LRP6 low density lipoprotein receptor-related protein 6
LTA lymphotoxin alpha
MAPK13 mitogen-activated protein kinase 13
MAPK8 mitogen-activated protein kinase 8
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MARK4 MAP/microtubule affinity-regulating kinase 4
MBOAT4 membrane bound O-acyltransferase domain containing 4
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MCHR1 melanin-concentrating hormone receptor 1
MECP2 methyl CpG binding protein 2
MFSD2A major facilitator superfamily domain containing 2A
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MIR378A microRNA 378a
MMP19 matrix metallopeptidase 19
MOGAT2 monoacylglycerol O-acyltransferase 2
MRAP2 melanocortin 2 receptor accessory protein 2
MTM1 myotubularin 1
NCOA3 nuclear receptor coactivator 3
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NHLH2 nescient helix loop helix 2
NMUR2 neuromedin U receptor 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NPBWR1 neuropeptides B/W receptor 1
NPC1L1 NPC1-like 1
NPY5R neuropeptide Y receptor Y5
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR2C2 nuclear receptor subfamily 2, group C, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OMA1 OMA1 zinc metallopeptidase
OPA1 optic atrophy 1 (autosomal dominant)
OSMR oncostatin M receptor
PASK PAS domain containing serine/threonine kinase
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE10A phosphodiesterase 10A
PGF placental growth factor
PHB2 prohibitin 2
PLIN1 perilipin 1
PLIN2 perilipin 2
PNLIP pancreatic lipase
PNRC2 proline-rich nuclear receptor coactivator 2
POMC proopiomelanocortin
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PRCP prolylcarboxypeptidase (angiotensinase C)
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRLH prolactin releasing hormone
PRLHR prolactin releasing hormone receptor
PROX1 prospero homeobox 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PYY peptide YY
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RCAN2 regulator of calcineurin 2
RGPD1 RANBP2-like and GRIP domain containing 1
RLN3 relaxin 3
RMI1 RecQ mediated genome instability 1
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC3 syndecan 3
SELM selenoprotein M
SEPN1 selenoprotein N, 1
SERTAD2 SERTA domain containing 2
SGMS2 sphingomyelin synthase 2
SIK3 SIK family kinase 3
SIM1 single-minded family bHLH transcription factor 1
SIRT3 sirtuin 3
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SOCS3 suppressor of cytokine signaling 3
SQSTM1 sequestosome 1
SRA1 steroid receptor RNA activator 1
SSFA2 sperm specific antigen 2
SST somatostatin
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TERF2IP telomeric repeat binding factor 2, interacting protein
TLR5 toll-like receptor 5
TNF tumor necrosis factor
TP53INP1 tumor protein p53 inducible nuclear protein 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TUB tubby bipartite transcription factor
UBB ubiquitin B
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
WRN Werner syndrome, RecQ helicase-like
ZC3H4 zinc finger CCCH-type containing 4
ZEB1 zinc finger E-box binding homeobox 1
ZFAND5 zinc finger, AN1-type domain 5
ZMPSTE24 zinc metallopeptidase STE24