abnormal substantia nigra pars compacta morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the posterior (dorsal) part of grey matter of the substantia nigra which contains large, polygonal, and densely packed dopamine-producing cells; pars compacta neurons are pigmented in many species (Mammalian Phenotype Ontology, MP_0013219)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0013219
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Genes

5 gene mutations causing the abnormal substantia nigra pars compacta morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
HYOU1 hypoxia up-regulated 1
IL6 interleukin 6
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
PARK2 parkin RBR E3 ubiquitin protein ligase
PITX3 paired-like homeodomain 3