abnormal substantia nigra morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the layer of grey substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis) (Mammalian Phenotype Ontology, MP_0000836)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000836
Similar Terms
Downloads & Tools

Genes

11 gene mutations causing the abnormal substantia nigra morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ESR2 estrogen receptor 2 (ER beta)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HIPK2 homeodomain interacting protein kinase 2
HYOU1 hypoxia up-regulated 1
IL6 interleukin 6
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
NR4A2 nuclear receptor subfamily 4, group A, member 2
PARK2 parkin RBR E3 ubiquitin protein ligase
PITX3 paired-like homeodomain 3
SPP1 secreted phosphoprotein 1