abnormal spongiotrophoblast layer morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors (Mammalian Phenotype Ontology, MP_0004255)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004255
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Genes

57 gene mutations causing the abnormal spongiotrophoblast layer morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ARID1A AT rich interactive domain 1A (SWI-like)
ARNT aryl hydrocarbon receptor nuclear translocator
ASCL2 achaete-scute family bHLH transcription factor 2
BIRC6 baculoviral IAP repeat containing 6
BRAF B-Raf proto-oncogene, serine/threonine kinase
C3 complement component 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHM choroideremia (Rab escort protein 1)
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
COMT catechol-O-methyltransferase
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
DLK1 delta-like 1 homolog (Drosophila)
DLX3 distal-less homeobox 3
DUSP9 dual specificity phosphatase 9
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
ELAVL1 ELAV like RNA binding protein 1
ERF Ets2 repressor factor
ESRRB estrogen-related receptor beta
ESX1 ESX homeobox 1
FBXW8 F-box and WD repeat domain containing 8
FGFR2 fibroblast growth factor receptor 2
FOXD3 forkhead box D3
G6PD glucose-6-phosphate dehydrogenase
GJB3 gap junction protein, beta 3, 31kDa
GJB5 gap junction protein, beta 5, 31.1kDa
HAND1 heart and neural crest derivatives expressed 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSF1 heat shock transcription factor 1
IL11RA interleukin 11 receptor, alpha
JUP junction plakoglobin
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK14 mitogen-activated protein kinase 14
MED1 mediator complex subunit 1
MPI mannose phosphate isomerase
MYH9 myosin, heavy chain 9, non-muscle
NCOA6 nuclear receptor coactivator 6
NODAL nodal growth differentiation factor
NRK Nik related kinase
NUMB numb homolog (Drosophila)
PBRM1 polybromo 1
PEG10 paternally expressed 10
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC1 placenta-specific 1
PRDM1 PR domain containing 1, with ZNF domain
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RBPJ recombination signal binding protein for immunoglobulin kappa J region
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SOCS3 suppressor of cytokine signaling 3
SP3 Sp3 transcription factor
STK11 serine/threonine kinase 11
ZFAT zinc finger and AT hook domain containing
ZFP36L1 ZFP36 ring finger protein-like 1