abnormal spleen red pulp morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation (Mammalian Phenotype Ontology, MP_0002356)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002356
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Genes

89 gene mutations causing the abnormal spleen red pulp morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AHR aryl hydrocarbon receptor
AKAP12 A kinase (PRKA) anchor protein 12
ALOX15 arachidonate 15-lipoxygenase
APCS amyloid P component, serum
ASL argininosuccinate lyase
ASXL1 additional sex combs like transcriptional regulator 1
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
BCL2 B-cell CLL/lymphoma 2
BCL3 B-cell CLL/lymphoma 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C6ORF25 chromosome 6 open reading frame 25
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNE1 cyclin E1
CCR7 chemokine (C-C motif) receptor 7
CD200 CD200 molecule
CDK6 cyclin-dependent kinase 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD2 chromodomain helicase DNA binding protein 2
COL10A1 collagen, type X, alpha 1
COMMD3-BMI1 COMMD3-BMI1 readthrough
CSF1 colony stimulating factor 1 (macrophage)
DCC DCC netrin 1 receptor
DKC1 dyskeratosis congenita 1, dyskerin
EPB41 erythrocyte membrane protein band 4.1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FADS2 fatty acid desaturase 2
FLT3 fms-related tyrosine kinase 3
FOXP3 forkhead box P3
FZD9 frizzled class receptor 9
GATA1 GATA binding protein 1 (globin transcription factor 1)
GDNF glial cell derived neurotrophic factor
GGT1 gamma-glutamyltransferase 1
GSTK1 glutathione S-transferase kappa 1
HK1 hexokinase 1
IFNG interferon, gamma
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL2 interleukin 2
IRF8 interferon regulatory factor 8
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK2 Janus kinase 2
LAMP2 lysosomal-associated membrane protein 2
LTB lymphotoxin beta (TNF superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN2B1 mannosidase, alpha, class 2B, member 1
MITF microphthalmia-associated transcription factor
MYB v-myb avian myeloblastosis viral oncogene homolog
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NCOA3 nuclear receptor coactivator 3
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NKX2-3 NK2 homeobox 3
NLRP3 NLR family, pyrin domain containing 3
PCSK1 proprotein convertase subtilisin/kexin type 1
PFDN1 prefoldin subunit 1
PGM3 phosphoglucomutase 3
PRDX2 peroxiredoxin 2
PRF1 perforin 1 (pore forming protein)
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPRC protein tyrosine phosphatase, receptor type, C
RASA3 RAS p21 protein activator 3
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RBL1 retinoblastoma-like 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
SELL selectin L
SH3BP2 SH3-domain binding protein 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOCS1 suppressor of cytokine signaling 1
SOS1 son of sevenless homolog 1 (Drosophila)
SPI1 Spi-1 proto-oncogene
SPTB spectrin, beta, erythrocytic
STEAP3 STEAP family member 3, metalloreductase
STIM1 stromal interaction molecule 1
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TNF tumor necrosis factor
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TPP2 tripeptidyl peptidase II
TRIB1 tribbles pseudokinase 1
TTC7A tetratricopeptide repeat domain 7A
UROS uroporphyrinogen III synthase
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
ZFPM1 zinc finger protein, FOG family member 1