abnormal spleen physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any functional anomaly of the organ that filters blood and stores red corpuscles and platelets (Mammalian Phenotype Ontology, MP_0008737)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008737
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65 gene mutations causing the abnormal spleen physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AIRE autoimmune regulator
AKAP13 A kinase (PRKA) anchor protein 13
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
BCL2 B-cell CLL/lymphoma 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBX2 chromobox homolog 2
CCNE1 cyclin E1
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CD247 CD247 molecule
CD28 CD28 molecule
CD99 CD99 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COMMD3-BMI1 COMMD3-BMI1 readthrough
CRLF2 cytokine receptor-like factor 2
CSF1 colony stimulating factor 1 (macrophage)
CTC1 CTS telomere maintenance complex component 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FLG filaggrin
FOXN1 forkhead box N1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IL13 interleukin 13
IL4 interleukin 4
ITFG2 integrin alpha FG-GAP repeat containing 2
KLF13 Kruppel-like factor 13
LIG1 ligase I, DNA, ATP-dependent
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NCOA3 nuclear receptor coactivator 3
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NTAN1 N-terminal asparagine amidase
OPRM1 opioid receptor, mu 1
POLB polymerase (DNA directed), beta
POMC proopiomelanocortin
PRDM1 PR domain containing 1, with ZNF domain
PRKCQ protein kinase C, theta
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SETD7 SET domain containing (lysine methyltransferase) 7
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIRT6 sirtuin 6
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
STEAP3 STEAP family member 3, metalloreductase
TICAM1 toll-like receptor adaptor molecule 1
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TLR2 toll-like receptor 2
TLR7 toll-like receptor 7
TLX1 T-cell leukemia homeobox 1
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TP53 tumor protein p53
TYK2 tyrosine kinase 2
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WT1 Wilms tumor 1