abnormal spleen periarteriolar lymphoid sheath morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the area of the spleen in which T cells surround the central arteriole (Mammalian Phenotype Ontology, MP_0002358)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002358
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Genes

14 gene mutations causing the abnormal spleen periarteriolar lymphoid sheath morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CCR7 chemokine (C-C motif) receptor 7
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IGHM immunoglobulin heavy constant mu
IL2RB interleukin 2 receptor, beta
JAK3 Janus kinase 3
LAT linker for activation of T cells
LTA lymphotoxin alpha
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NKX2-3 NK2 homeobox 3
SGPL1 sphingosine-1-phosphate lyase 1
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TOM1L2 target of myb1-like 2 (chicken)