abnormal somatic hypermutation frequency Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells (Mammalian Phenotype Ontology, MP_0004815)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004815
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Genes

14 gene mutations causing the abnormal somatic hypermutation frequency phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AICDA activation-induced cytidine deaminase
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL6 B-cell CLL/lymphoma 6
EXO1 exonuclease 1
FCAMR Fc receptor, IgA, IgM, high affinity
HOXC4 homeobox C4
MSH2 mutS homolog 2
PCNA proliferating cell nuclear antigen
PKN1 protein kinase N1
POLB polymerase (DNA directed), beta
POLQ polymerase (DNA directed), theta
REV1 REV1, polymerase (DNA directed)
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
UNG uracil-DNA glycosylase