abnormal serotonin level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the amount of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity (Mammalian Phenotype Ontology, MP_0005322)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005322
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Genes

59 gene mutations causing the abnormal serotonin level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADGRL3 adhesion G protein-coupled receptor L3
AP3B1 adaptor-related protein complex 3, beta 1 subunit
AP3D1 adaptor-related protein complex 3, delta 1 subunit
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
BDNF brain-derived neurotrophic factor
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
CELF6 CUGBP, Elav-like family member 6
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DISC1 disrupted in schizophrenia 1
DTNBP1 dystrobrevin binding protein 1
EN1 engrailed homeobox 1
EN2 engrailed homeobox 2
ESR2 estrogen receptor 2 (ER beta)
FOXP2 forkhead box P2
FYN FYN proto-oncogene, Src family tyrosine kinase
GRIA1 glutamate receptor, ionotropic, AMPA 1
GSTM5 glutathione S-transferase mu 5
GTF2IRD1 GTF2I repeat domain containing 1
HPS1 Hermansky-Pudlak syndrome 1
HPS3 Hermansky-Pudlak syndrome 3
HPS4 Hermansky-Pudlak syndrome 4
HPS5 Hermansky-Pudlak syndrome 5
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
LPAR1 lysophosphatidic acid receptor 1
LRP5 low density lipoprotein receptor-related protein 5
LYST lysosomal trafficking regulator
MAGED1 melanoma antigen family D1
MAOA monoamine oxidase A
MCHR1 melanin-concentrating hormone receptor 1
MECP2 methyl CpG binding protein 2
MITF microphthalmia-associated transcription factor
MPST mercaptopyruvate sulfurtransferase
NENF neudesin neurotrophic factor
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NR4A2 nuclear receptor subfamily 4, group A, member 2
PAH phenylalanine hydroxylase
PTS 6-pyruvoyltetrahydropterin synthase
RAB27A RAB27A, member RAS oncogene family
RAB27B RAB27B, member RAS oncogene family
S100A10 S100 calcium binding protein A10
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC35D3 solute carrier family 35, member D3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP25 synaptosomal-associated protein, 25kDa
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STX1A syntaxin 1A (brain)
TAAR1 trace amine associated receptor 1
TDO2 tryptophan 2,3-dioxygenase
TH tyrosine hydroxylase
TNC tenascin C
TNF tumor necrosis factor
TPH1 tryptophan hydroxylase 1
TPH2 tryptophan hydroxylase 2
UBE3A ubiquitin protein ligase E3A