abnormal seizure response to pharmacological agent Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the seizure activity response that is brought about by treatment with pharmacological agents (Mammalian Phenotype Ontology, MP_0000950)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000950
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Genes

108 gene mutations causing the abnormal seizure response to pharmacological agent phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKAP5 A kinase (PRKA) anchor protein 5
AKT3 v-akt murine thymoma viral oncogene homolog 3
AMPH amphiphysin
AP3M2 adaptor-related protein complex 3, mu 2 subunit
ARX aristaless related homeobox
AVPR1B arginine vasopressin receptor 1B
BHLHE40 basic helix-loop-helix family, member e40
BSN bassoon presynaptic cytomatrix protein
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CIT citron rho-interacting serine/threonine kinase
CKB creatine kinase, brain
CLCN3 chloride channel, voltage-sensitive 3
CLN3 ceroid-lipofuscinosis, neuronal 3
CNR1 cannabinoid receptor 1 (brain)
CNTN2 contactin 2 (axonal)
DRD2 dopamine receptor D2
EFHC1 EF-hand domain (C-terminal) containing 1
FAIM2 Fas apoptotic inhibitory molecule 2
FGF14 fibroblast growth factor 14
FGF22 fibroblast growth factor 22
FGF7 fibroblast growth factor 7
FZD9 frizzled class receptor 9
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAL galanin/GMAP prepropeptide
GDI1 GDP dissociation inhibitor 1
GFAP glial fibrillary acidic protein
GLRA1 glycine receptor, alpha 1
GLRA3 glycine receptor, alpha 3
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIK5 glutamate receptor, ionotropic, kainate 5
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRM5 glutamate receptor, metabotropic 5
GRM7 glutamate receptor, metabotropic 7
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HCRTR1 hypocretin (orexin) receptor 1
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
JUN jun proto-oncogene
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
KCNK2 potassium channel, two pore domain subfamily K, member 2
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KLK8 kallikrein-related peptidase 8
LGI1 leucine-rich, glioma inactivated 1
LHX6 LIM homeobox 6
MAPK10 mitogen-activated protein kinase 10
MAPT microtubule-associated protein tau
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MECP2 methyl CpG binding protein 2
MT3 metallothionein 3
NEUROD2 neuronal differentiation 2
NOS2 nitric oxide synthase 2, inducible
NPY neuropeptide Y
NPY2R neuropeptide Y receptor Y2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRP2 neuropilin 2
OPRD1 opioid receptor, delta 1
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PANX1 pannexin 1
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDE8A phosphodiesterase 8A
PDYN prodynorphin
PLAUR plasminogen activator, urokinase receptor
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCL1 phospholipase C-like 1
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PRICKLE2 prickle homolog 2 (Drosophila)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
RYR2 ryanodine receptor 2 (cardiac)
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN2B sodium channel, voltage gated, type II beta subunit
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SEZ6 seizure related 6 homolog (mouse)
SLC10A4 solute carrier family 10, member 4
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
SYNGAP1 synaptic Ras GTPase activating protein 1
SZT2 seizure threshold 2 homolog (mouse)
TRIM3 tripartite motif containing 3
TRPC5 transient receptor potential cation channel, subfamily C, member 5