abnormal rostral-caudal axis patterning Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the development or formation of the axis that runs from the head to the tail of the body (Mammalian Phenotype Ontology, MP_0005221)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005221
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Genes

106 gene mutations causing the abnormal rostral-caudal axis patterning phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AMN amnion associated transmembrane protein
APC adenomatous polyposis coli
APH1A APH1A gamma secretase subunit
AXIN1 axin 1
BMP4 bone morphogenetic protein 4
BMP7 bone morphogenetic protein 7
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BPTF bromodomain PHD finger transcription factor
CC2D2A coiled-coil and C2 domain containing 2A
CCDC160 coiled-coil domain containing 160
CCNF cyclin F
CDX2 caudal type homeobox 2
CNBP CCHC-type zinc finger, nucleic acid binding protein
CSK c-src tyrosine kinase
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DAD1 defender against cell death 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG3 discs, large homolog 3 (Drosophila)
DLL1 delta-like 1 (Drosophila)
DLL3 delta-like 3 (Drosophila)
DNM1L dynamin 1-like
EFNB2 ephrin-B2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EXOC4 exocyst complex component 4
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR1 fibroblast growth factor receptor 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
FOXA2 forkhead box A2
FOXB1 forkhead box B1
FRS2 fibroblast growth factor receptor substrate 2
FURIN furin (paired basic amino acid cleaving enzyme)
GATA4 GATA binding protein 4
GDF11 growth differentiation factor 11
GDF3 growth differentiation factor 3
GLI2 GLI family zinc finger 2
HAND1 heart and neural crest derivatives expressed 1
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HHEX hematopoietically expressed homeobox
HIRA histone cell cycle regulator
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KDM6A lysine (K)-specific demethylase 6A
KIF3A kinesin family member 3A
KMT2A lysine (K)-specific methyltransferase 2A
KMT2B lysine (K)-specific methyltransferase 2B
LDB1 LIM domain binding 1
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LHX1 LIM homeobox 1
LIAS lipoic acid synthetase
LMO2 LIM domain only 2 (rhombotin-like 1)
MAPK1 mitogen-activated protein kinase 1
MED12 mediator complex subunit 12
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2
MIB1 mindbomb E3 ubiquitin protein ligase 1
MIXL1 Mix paired-like homeobox
MPI mannose phosphate isomerase
NCKAP1 NCK-associated protein 1
NCSTN nicastrin
NODAL nodal growth differentiation factor
NOG noggin
NOTCH1 notch 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
NSD1 nuclear receptor binding SET domain protein 1
NUMB numb homolog (Drosophila)
OPA1 optic atrophy 1 (autosomal dominant)
OTX2 orthodenticle homeobox 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
POGLUT1 protein O-glucosyltransferase 1
PPAP2B phosphatidic acid phosphatase type 2B
PRKCI protein kinase C, iota
PSEN1 presenilin 1
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAD51D RAD51 paralog D
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RDH10 retinol dehydrogenase 10 (all-trans)
RIPPLY2 ripply transcriptional repressor 2
RNASEH2B ribonuclease H2, subunit B
ROR2 receptor tyrosine kinase-like orphan receptor 2
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe)
SIX3 SIX homeobox 3
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SOX17 SRY (sex determining region Y)-box 17
SP8 Sp8 transcription factor
T T, brachyury homolog (mouse)
TCF15 transcription factor 15 (basic helix-loop-helix)
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCTN1 tectonic family member 1
TCTN2 tectonic family member 2
TDGF1 teratocarcinoma-derived growth factor 1
TENM4 teneurin transmembrane protein 4
TMED2 transmembrane emp24 domain trafficking protein 2
TXNRD1 thioredoxin reductase 1
VCL vinculin
WLS wntless Wnt ligand secretion mediator
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A
ZIC3 Zic family member 3