abnormal roof plate morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the single row of specialized glial cells that occupies the dorsal midline of the developing neural tube along the entire anterior-posterior axis; the roof plate serves as a critical embryonic signaling center for the organization of dorsal neuronal cell types, and acts as a barrier preventing axons and cells migrating across the dorsal midline (Mammalian Phenotype Ontology, MP_0000923)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000923
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Genes

8 gene mutations causing the abnormal roof plate morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARHGAP35 Rho GTPase activating protein 35
FOXC1 forkhead box C1
LMX1A LIM homeobox transcription factor 1, alpha
LUZP1 leucine zipper protein 1
MSX1 msh homeobox 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
TMEM67 transmembrane protein 67
ZIC2 Zic family member 2