abnormal regulatory t cell physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function (Mammalian Phenotype Ontology, MP_0004946)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004946
Similar Terms
Downloads & Tools


21 gene mutations causing the abnormal regulatory t cell physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADGRE1 adhesion G protein-coupled receptor E1
AIRE autoimmune regulator
CCL1 chemokine (C-C motif) ligand 1
CD247 CD247 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
DTX1 deltex 1, E3 ubiquitin ligase
FOXP3 forkhead box P3
GPR15 G protein-coupled receptor 15
IDO2 indoleamine 2,3-dioxygenase 2
IL10 interleukin 10
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL9R interleukin 9 receptor
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RXRA retinoid X receptor, alpha
SELL selectin L
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa