abnormal primitive streak morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm (Mammalian Phenotype Ontology, MP_0002231)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002231
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Genes

113 gene mutations causing the abnormal primitive streak morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
AMN amnion associated transmembrane protein
APC adenomatous polyposis coli
ATMIN ATM interactor
AXIN2 axin 2
B9D1 B9 protein domain 1
BICC1 BicC family RNA binding protein 1
BMP4 bone morphogenetic protein 4
BMPR1A bone morphogenetic protein receptor, type IA
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BPTF bromodomain PHD finger transcription factor
BRCA1 breast cancer 1, early onset
C2CD3 C2 calcium-dependent domain containing 3
CCDC40 coiled-coil domain containing 40
CHD8 chromodomain helicase DNA binding protein 8
CLUAP1 clusterin associated protein 1
CRB2 crumbs family member 2
DACT1 dishevelled-binding antagonist of beta-catenin 1
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DLL1 delta-like 1 (Drosophila)
DNAH11 dynein, axonemal, heavy chain 11
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
EOMES eomesodermin
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR1 fibroblast growth factor receptor 1
FOXA2 forkhead box A2
FOXD3 forkhead box D3
FOXF1 forkhead box F1
FOXH1 forkhead box H1
FOXJ1 forkhead box J1
FRS2 fibroblast growth factor receptor substrate 2
GDF3 growth differentiation factor 3
HHEX hematopoietically expressed homeobox
HIRA histone cell cycle regulator
HNF4A hepatocyte nuclear factor 4, alpha
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HTT huntingtin
IFT122 intraflagellar transport 122
IFT172 intraflagellar transport 172
IFT57 intraflagellar transport 57
IFT88 intraflagellar transport 88
INTU inturned planar cell polarity protein
INVS inversin
KIAA0586 KIAA0586
KIF3A kinesin family member 3A
KIF3B kinesin family member 3B
LDB1 LIM domain binding 1
LEFTY2 left-right determination factor 2
LHX1 LIM homeobox 1
MACF1 microtubule-actin crosslinking factor 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MBD4 methyl-CpG binding domain protein 4
MESDC2 mesoderm development candidate 2
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2
MIXL1 Mix paired-like homeobox
MKS1 Meckel syndrome, type 1
MYL1 myosin, light chain 1, alkali; skeletal, fast
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NCKAP1 NCK-associated protein 1
NFE2L1 nuclear factor, erythroid 2-like 1
NODAL nodal growth differentiation factor
NOTO notochord homeobox
NR6A1 nuclear receptor subfamily 6, group A, member 1
NSD1 nuclear receptor binding SET domain protein 1
NUP133 nucleoporin 133kDa
OTX2 orthodenticle homeobox 2
PIFO primary cilia formation
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PKD2 polycystic kidney disease 2 (autosomal dominant)
PKNOX1 PBX/knotted 1 homeobox 1
PNN pinin, desmosome associated protein
POFUT2 protein O-fucosyltransferase 2
PPAP2B phosphatidic acid phosphatase type 2B
PRICKLE1 prickle homolog 1 (Drosophila)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
RAB7A RAB7A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RFX3 regulatory factor X, 3 (influences HLA class II expression)
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SALL4 spalt-like transcription factor 4
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SRF serum response factor (c-fos serum response element-binding transcription factor)
SUFU suppressor of fused homolog (Drosophila)
T T, brachyury homolog (mouse)
TBX6 T-box 6
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCTN1 tectonic family member 1
TCTN2 tectonic family member 2
TDGF1 teratocarcinoma-derived growth factor 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TLX2 T-cell leukemia homeobox 2
TMEM67 transmembrane protein 67
TPT1 tumor protein, translationally-controlled 1
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRIM33 tripartite motif containing 33
TSG101 tumor susceptibility 101
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
VANGL2 VANGL planar cell polarity protein 2
WDR35 WD repeat domain 35
WLS wntless Wnt ligand secretion mediator
WNT3 wingless-type MMTV integration site family, member 3
WNT5A wingless-type MMTV integration site family, member 5A
YAP1 Yes-associated protein 1
ZBTB17 zinc finger and BTB domain containing 17
ZIC3 Zic family member 3