abnormal placenta morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the organ of metabolic interchange between fetus and mother, which is partly of embryonic origin and partly of maternal origin (Mammalian Phenotype Ontology, MP_0001711)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001711
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Genes

326 gene mutations causing the abnormal placenta morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABI1 abl-interactor 1
ADAM17 ADAM metallopeptidase domain 17
ADM adrenomedullin
AGO2 argonaute RISC catalytic component 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
AMOT angiomotin
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARID1A AT rich interactive domain 1A (SWI-like)
ARNT aryl hydrocarbon receptor nuclear translocator
ASCL2 achaete-scute family bHLH transcription factor 2
ATAD3A ATPase family, AAA domain containing 3A
ATF2 activating transcription factor 2
ATP11A ATPase, class VI, type 11A
ATR ATR serine/threonine kinase
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BIRC6 baculoviral IAP repeat containing 6
BMP5 bone morphogenetic protein 5
BPTF bromodomain PHD finger transcription factor
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
C3 complement component 3
CALCRL calcitonin receptor-like
CAPN2 calpain 2, (m/II) large subunit
CBS cystathionine-beta-synthase
CCDC160 coiled-coil domain containing 160
CCNF cyclin F
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDK7 cyclin-dependent kinase 7
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDX2 caudal type homeobox 2
CELF1 CUGBP, Elav-like family member 1
CHM choroideremia (Rab escort protein 1)
CHMP5 charged multivesicular body protein 5
CHTOP chromatin target of PRMT1
CHUK conserved helix-loop-helix ubiquitous kinase
CIR1 corepressor interacting with RBPJ, 1
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
COMMD1 copper metabolism (Murr1) domain containing 1
COMT catechol-O-methyltransferase
COPS2 COP9 signalosome subunit 2
CR1L complement component (3b/4b) receptor 1-like
CRB2 crumbs family member 2
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSNK2B casein kinase 2, beta polypeptide
CTBP2 C-terminal binding protein 2
CUL3 cullin 3
CUL4B cullin 4B
CUL7 cullin 7
CXADR coxsackie virus and adenovirus receptor
CXXC1 CXXC finger protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAD1 defender against cell death 1
DAP3 death associated protein 3
DAXX death-domain associated protein
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DLL4 delta-like 4 (Drosophila)
DLX3 distal-less homeobox 3
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNM1L dynamin 1-like
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
DPH3 diphthamide biosynthesis 3
DUSP9 dual specificity phosphatase 9
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELAVL1 ELAV like RNA binding protein 1
ELF5 E74-like factor 5 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EOMES eomesodermin
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPCAM epithelial cell adhesion molecule
EPO erythropoietin
EPOR erythropoietin receptor
ERF Ets2 repressor factor
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ERN1 endoplasmic reticulum to nucleus signaling 1
ERVFRD-1 endogenous retrovirus group FRD, member 1
ESRRB estrogen-related receptor beta
ESX1 ESX homeobox 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV2 ets variant 2
F2R coagulation factor II (thrombin) receptor
FBN1 fibrillin 1
FBXL5 F-box and leucine-rich repeat protein 5
FBXO5 F-box protein 5
FBXW8 F-box and WD repeat domain containing 8
FEN1 flap structure-specific endonuclease 1
FGFR2 fibroblast growth factor receptor 2
FGFRL1 fibroblast growth factor receptor-like 1
FGG fibrinogen gamma chain
FKBP4 FK506 binding protein 4, 59kDa
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FOXD3 forkhead box D3
FOXF1 forkhead box F1
FRS2 fibroblast growth factor receptor substrate 2
FURIN furin (paired basic amino acid cleaving enzyme)
FZD5 frizzled class receptor 5
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
G6PD glucose-6-phosphate dehydrogenase
GAB1 GRB2-associated binding protein 1
GCM1 glial cells missing homolog 1 (Drosophila)
GHR growth hormone receptor
GJB2 gap junction protein, beta 2, 26kDa
GJB3 gap junction protein, beta 3, 31kDa
GJB5 gap junction protein, beta 5, 31.1kDa
GJC1 gap junction protein, gamma 1, 45kDa
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1
GPC3 glypican 3
GRB10 growth factor receptor-bound protein 10
GRB2 growth factor receptor-bound protein 2
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HAND1 heart and neural crest derivatives expressed 1
HCST hematopoietic cell signal transducer
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIRA histone cell cycle regulator
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HMX3 H6 family homeobox 3
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HOXA13 homeobox A13
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSF1 heat shock transcription factor 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HUS1 HUS1 checkpoint homolog (S. pombe)
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IGF2 insulin-like growth factor 2
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGF2R insulin-like growth factor 2 receptor
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL10 interleukin 10
IL11RA interleukin 11 receptor, alpha
IL15 interleukin 15
IL2RG interleukin 2 receptor, gamma
IL5 interleukin 5
IPMK inositol polyphosphate multikinase
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB7 integrin, beta 7
ITGB8 integrin, beta 8
JUP junction plakoglobin
KAT7 K(lysine) acetyltransferase 7
KCNQ1OT1 KCNQ1 opposite strand/antisense transcript 1 (non-protein coding)
KDM6A lysine (K)-specific demethylase 6A
KRT8 keratin 8, type II
LAMA1 laminin, alpha 1
LAMA5 laminin, alpha 5
LDB1 LIM domain binding 1
LEFTY2 left-right determination factor 2
LIF leukemia inhibitory factor
LIFR leukemia inhibitory factor receptor alpha
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LPAR3 lysophosphatidic acid receptor 3
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK7 mitogen-activated protein kinase 7
MDFI MyoD family inhibitor
MECOM MDS1 and EVI1 complex locus
MECP2 methyl CpG binding protein 2
MED1 mediator complex subunit 1
MED24 mediator complex subunit 24
MEG3 maternally expressed 3 (non-protein coding)
MEST mesoderm specific transcript
MET MET proto-oncogene, receptor tyrosine kinase
MFN2 mitofusin 2
MIB1 mindbomb E3 ubiquitin protein ligase 1
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MPI mannose phosphate isomerase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NCKAP1 NCK-associated protein 1
NCOA1 nuclear receptor coactivator 1
NCOA6 nuclear receptor coactivator 6
NF2 neurofibromin 2 (merlin)
NOA1 nitric oxide associated 1
NODAL nodal growth differentiation factor
NOTCH1 notch 1
NOTCH2 notch 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR6A1 nuclear receptor subfamily 6, group A, member 1
NRK Nik related kinase
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUMB numb homolog (Drosophila)
OVOL2 ovo-like zinc finger 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PALB2 partner and localizer of BRCA2
PARVA parvin, alpha
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PBRM1 polybromo 1
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PEG10 paternally expressed 10
PGF placental growth factor
PGR progesterone receptor
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLAC1 placenta-specific 1
PLK2 polo-like kinase 2
PMM2 phosphomannomutase 2
PNPLA6 patatin-like phospholipase domain containing 6
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PON3 paraoxonase 3
POU2F1 POU class 2 homeobox 1
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPP1R8 protein phosphatase 1, regulatory subunit 8
PRDM1 PR domain containing 1, with ZNF domain
PRLR prolactin receptor
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAD23B RAD23 homolog B (S. cerevisiae)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RANGAP1 Ran GTPase activating protein 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RB1 retinoblastoma 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RECQL4 RecQ protein-like 4
RICTOR RPTOR independent companion of MTOR, complex 2
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPL38 ribosomal protein L38
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RPTOR regulatory associated protein of MTOR, complex 1
RSPO3 R-spondin 3
RTEL1 regulator of telomere elongation helicase 1
RTL1 retrotransposon-like 1
RXRA retinoid X receptor, alpha
RYBP RING1 and YY1 binding protein
SALL4 spalt-like transcription factor 4
SAV1 salvador family WW domain containing protein 1
SDC4 syndecan 4
SENP1 SUMO1/sentrin specific peptidase 1
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SETD2 SET domain containing 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SNX13 sorting nexin 13
SOCS3 suppressor of cytokine signaling 3
SOX2 SRY (sex determining region Y)-box 2
SP3 Sp3 transcription factor
SPINT1 serine peptidase inhibitor, Kunitz type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SS18 synovial sarcoma translocation, chromosome 18
SSB Sjogren syndrome antigen B (autoantigen La)
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STK11 serine/threonine kinase 11
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
T T, brachyury homolog (mouse)
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAL1 T-cell acute lymphocytic leukemia 1
TBP TATA box binding protein
TBX4 T-box 4
TEAD4 TEA domain family member 4
TENM4 teneurin transmembrane protein 4
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFDP1 transcription factor Dp-1
TFEB transcription factor EB
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGIF1 TGFB-induced factor homeobox 1
THBD thrombomodulin
TLE3 transducin-like enhancer of split 3
TLN1 talin 1
TMED2 transmembrane emp24 domain trafficking protein 2
TPT1 tumor protein, translationally-controlled 1
TRIP12 thyroid hormone receptor interactor 12
TRRAP transformation/transcription domain-associated protein
TSIX TSIX transcript, XIST antisense RNA
TTPA tocopherol (alpha) transfer protein
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
TYROBP TYRO protein tyrosine kinase binding protein
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBP1 upstream binding protein 1 (LBP-1a)
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UBR5 ubiquitin protein ligase E3 component n-recognin 5
USP9X ubiquitin specific peptidase 9, X-linked
UTF1 undifferentiated embryonic cell transcription factor 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WASF2 WAS protein family, member 2
WDR83 WD repeat domain 83
WNK1 WNK lysine deficient protein kinase 1
WNT2 wingless-type MMTV integration site family member 2
WNT6 wingless-type MMTV integration site family, member 6
WNT7B wingless-type MMTV integration site family, member 7B
XIST X inactive specific transcript (non-protein coding)
ZFAT zinc finger and AT hook domain containing
ZFP36L1 ZFP36 ring finger protein-like 1
ZPR1 ZPR1 zinc finger