abnormal placenta labyrinth morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood, and is the site where the exchange of nutrients and waste products occurs between the maternal and fetal circulation (Mammalian Phenotype Ontology, MP_0001716)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001716
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Genes

141 gene mutations causing the abnormal placenta labyrinth morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADM adrenomedullin
AGO2 argonaute RISC catalytic component 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARNT aryl hydrocarbon receptor nuclear translocator
ASCL2 achaete-scute family bHLH transcription factor 2
ATF2 activating transcription factor 2
BIRC6 baculoviral IAP repeat containing 6
BRAF B-Raf proto-oncogene, serine/threonine kinase
C3 complement component 3
CALCRL calcitonin receptor-like
CBS cystathionine-beta-synthase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDX2 caudal type homeobox 2
CHM choroideremia (Rab escort protein 1)
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTBP2 C-terminal binding protein 2
CUL4B cullin 4B
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
DLX3 distal-less homeobox 3
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPH3 diphthamide biosynthesis 3
DUSP9 dual specificity phosphatase 9
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
ELAVL1 ELAV like RNA binding protein 1
EPCAM epithelial cell adhesion molecule
ERF Ets2 repressor factor
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ERN1 endoplasmic reticulum to nucleus signaling 1
ERVFRD-1 endogenous retrovirus group FRD, member 1
ESRRB estrogen-related receptor beta
ESX1 ESX homeobox 1
ETV2 ets variant 2
FBXW8 F-box and WD repeat domain containing 8
FGFR2 fibroblast growth factor receptor 2
FGFRL1 fibroblast growth factor receptor-like 1
FGG fibrinogen gamma chain
FOSL1 FOS-like antigen 1
FOXD3 forkhead box D3
FZD5 frizzled class receptor 5
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
G6PD glucose-6-phosphate dehydrogenase
GAB1 GRB2-associated binding protein 1
GCM1 glial cells missing homolog 1 (Drosophila)
GJB2 gap junction protein, beta 2, 26kDa
GJB3 gap junction protein, beta 3, 31kDa
GPC3 glypican 3
GRB2 growth factor receptor-bound protein 2
HAND1 heart and neural crest derivatives expressed 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HOXA13 homeobox A13
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSF1 heat shock transcription factor 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HUS1 HUS1 checkpoint homolog (S. pombe)
IL10 interleukin 10
IL11RA interleukin 11 receptor, alpha
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB8 integrin, beta 8
LAMA5 laminin, alpha 5
LLGL2 lethal giant larvae homolog 2 (Drosophila)
MAP2K1 mitogen-activated protein kinase kinase 1
MAP3K3 mitogen-activated protein kinase kinase kinase 3
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK7 mitogen-activated protein kinase 7
MED1 mediator complex subunit 1
MED24 mediator complex subunit 24
MET MET proto-oncogene, receptor tyrosine kinase
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae)
MPI mannose phosphate isomerase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
NCOA6 nuclear receptor coactivator 6
NODAL nodal growth differentiation factor
NOTCH2 notch 2
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUMB numb homolog (Drosophila)
OVOL2 ovo-like zinc finger 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PALB2 partner and localizer of BRCA2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PBRM1 polybromo 1
PDGFB platelet-derived growth factor beta polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEG10 paternally expressed 10
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLK2 polo-like kinase 2
PNPLA6 patatin-like phospholipase domain containing 6
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PRDM1 PR domain containing 1, with ZNF domain
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RICTOR RPTOR independent companion of MTOR, complex 2
RSPO3 R-spondin 3
RTL1 retrotransposon-like 1
RXRA retinoid X receptor, alpha
SAV1 salvador family WW domain containing protein 1
SDC4 syndecan 4
SENP1 SUMO1/sentrin specific peptidase 1
SETD2 SET domain containing 2
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SNX13 sorting nexin 13
SOCS3 suppressor of cytokine signaling 3
SP3 Sp3 transcription factor
SPINT1 serine peptidase inhibitor, Kunitz type 1
SS18 synovial sarcoma translocation, chromosome 18
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STK11 serine/threonine kinase 11
TAL1 T-cell acute lymphocytic leukemia 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR1 transforming growth factor, beta receptor 1
TGIF1 TGFB-induced factor homeobox 1
TMED2 transmembrane emp24 domain trafficking protein 2
TRIP12 thyroid hormone receptor interactor 12
TTPA tocopherol (alpha) transfer protein
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBP1 upstream binding protein 1 (LBP-1a)
UBR4 ubiquitin protein ligase E3 component n-recognin 4
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
WASF2 WAS protein family, member 2
WNK1 WNK lysine deficient protein kinase 1
WNT2 wingless-type MMTV integration site family member 2
XIST X inactive specific transcript (non-protein coding)
ZFP36L1 ZFP36 ring finger protein-like 1