abnormal placenta development Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother (Mammalian Phenotype Ontology, MP_0001712)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001712
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Genes

146 gene mutations causing the abnormal placenta development phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABI1 abl-interactor 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ARNT aryl hydrocarbon receptor nuclear translocator
ASCL2 achaete-scute family bHLH transcription factor 2
ATAD3A ATPase family, AAA domain containing 3A
AURKB aurora kinase B
BPTF bromodomain PHD finger transcription factor
CCDC160 coiled-coil domain containing 160
CCNF cyclin F
CDX2 caudal type homeobox 2
CHM choroideremia (Rab escort protein 1)
CHMP5 charged multivesicular body protein 5
COMMD1 copper metabolism (Murr1) domain containing 1
CR1L complement component (3b/4b) receptor 1-like
CRB2 crumbs family member 2
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTBP2 C-terminal binding protein 2
CUL7 cullin 7
CXXC1 CXXC finger protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAD1 defender against cell death 1
DAP3 death associated protein 3
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLX3 distal-less homeobox 3
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
DPH3 diphthamide biosynthesis 3
ELAVL1 ELAV like RNA binding protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
ERF Ets2 repressor factor
ESRRB estrogen-related receptor beta
ESX1 ESX homeobox 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV2 ets variant 2
F2R coagulation factor II (thrombin) receptor
FBXL5 F-box and leucine-rich repeat protein 5
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FKBP4 FK506 binding protein 4, 59kDa
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FOXF1 forkhead box F1
FURIN furin (paired basic amino acid cleaving enzyme)
GCM1 glial cells missing homolog 1 (Drosophila)
GJB2 gap junction protein, beta 2, 26kDa
GJB3 gap junction protein, beta 3, 31kDa
GJB5 gap junction protein, beta 5, 31.1kDa
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1
GRB2 growth factor receptor-bound protein 2
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
HAND1 heart and neural crest derivatives expressed 1
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIRA histone cell cycle regulator
HMX3 H6 family homeobox 3
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HUS1 HUS1 checkpoint homolog (S. pombe)
IL11RA interleukin 11 receptor, alpha
IL15 interleukin 15
IPMK inositol polyphosphate multikinase
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB8 integrin, beta 8
KAT7 K(lysine) acetyltransferase 7
LAMA1 laminin, alpha 1
LDB1 LIM domain binding 1
LEFTY2 left-right determination factor 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MET MET proto-oncogene, receptor tyrosine kinase
MIB1 mindbomb E3 ubiquitin protein ligase 1
MPI mannose phosphate isomerase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NCKAP1 NCK-associated protein 1
NCOA1 nuclear receptor coactivator 1
NCOA6 nuclear receptor coactivator 6
NF2 neurofibromin 2 (merlin)
NODAL nodal growth differentiation factor
NOTCH2 notch 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR6A1 nuclear receptor subfamily 6, group A, member 1
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PGR progesterone receptor
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLAC1 placenta-specific 1
PLK2 polo-like kinase 2
PNPLA6 patatin-like phospholipase domain containing 6
POU2F1 POU class 2 homeobox 1
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPP1R8 protein phosphatase 1, regulatory subunit 8
PRDM1 PR domain containing 1, with ZNF domain
PRLR prolactin receptor
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RANGAP1 Ran GTPase activating protein 1
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RTEL1 regulator of telomere elongation helicase 1
RTL1 retrotransposon-like 1
SETD2 SET domain containing 2
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SOCS3 suppressor of cytokine signaling 3
SOX2 SRY (sex determining region Y)-box 2
SPINT1 serine peptidase inhibitor, Kunitz type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SS18 synovial sarcoma translocation, chromosome 18
STK11 serine/threonine kinase 11
T T, brachyury homolog (mouse)
TBX4 T-box 4
TENM4 teneurin transmembrane protein 4
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFDP1 transcription factor Dp-1
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TMED2 transmembrane emp24 domain trafficking protein 2
TPT1 tumor protein, translationally-controlled 1
TRIP12 thyroid hormone receptor interactor 12
TSIX TSIX transcript, XIST antisense RNA
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UBR5 ubiquitin protein ligase E3 component n-recognin 5
USP9X ubiquitin specific peptidase 9, X-linked
UTF1 undifferentiated embryonic cell transcription factor 1
VCAM1 vascular cell adhesion molecule 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
WDR83 WD repeat domain 83
WNT2 wingless-type MMTV integration site family member 2
WNT6 wingless-type MMTV integration site family, member 6
WNT7B wingless-type MMTV integration site family, member 7B
ZFP36L1 ZFP36 ring finger protein-like 1