abnormal pancreatic islet morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the clusters of hormone-producing cells that are scattered throughout the pancreas (Mammalian Phenotype Ontology, MP_0005215)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005215
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Genes

156 gene mutations causing the abnormal pancreatic islet morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ADIPOR2 adiponectin receptor 2
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AKAP5 A kinase (PRKA) anchor protein 5
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALMS1 Alstrom syndrome protein 1
ALX3 ALX homeobox 3
ANXA7 annexin A7
AQP7 aquaporin 7
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARX aristaless related homeobox
ASIP agouti signaling protein
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATXN2 ataxin 2
B2M beta-2-microglobulin
BAD BCL2-associated agonist of cell death
BGLAP bone gamma-carboxyglutamate (gla) protein
BID BH3 interacting domain death agonist
BRD2 bromodomain containing 2
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CADM1 cell adhesion molecule 1
CCDC80 coiled-coil domain containing 80
CCKBR cholecystokinin B receptor
CD38 CD38 molecule
CDK4 cyclin-dependent kinase 4
CES1 carboxylesterase 1
CLOCK clock circadian regulator
COL1A1 collagen, type I, alpha 1
COL5A3 collagen, type V, alpha 3
CPE carboxypeptidase E
CREBBP CREB binding protein
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTF1 cardiotrophin 1
CYB5R4 cytochrome b5 reductase 4
CYS1 cystin 1
DACH1 dachshund family transcription factor 1
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
E2F1 E2F transcription factor 1
EGFR epidermal growth factor receptor
EHD4 EH-domain containing 4
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ERO1LB ERO1-like beta (S. cerevisiae)
ESR2 estrogen receptor 2 (ER beta)
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FFAR4 free fatty acid receptor 4
FGF10 fibroblast growth factor 10
FSTL3 follistatin-like 3 (secreted glycoprotein)
G6PC3 glucose 6 phosphatase, catalytic, 3
GCG glucagon
GCGR glucagon receptor
GCK glucokinase (hexokinase 4)
GDF11 growth differentiation factor 11
GHR growth hormone receptor
GLIS3 GLIS family zinc finger 3
GPR39 G protein-coupled receptor 39
HADH hydroxyacyl-CoA dehydrogenase
HHIP hedgehog interacting protein
HIPK3 homeodomain interacting protein kinase 3
HMGA1 high mobility group AT-hook 1
HNF1A HNF1 homeobox A
HPRT1 hypoxanthine phosphoribosyltransferase 1
ICOS inducible T-cell co-stimulator
IL3 interleukin 3
IL6 interleukin 6
ILDR2 immunoglobulin-like domain containing receptor 2
INS insulin
INSL5 insulin-like 5
INSM1 insulinoma-associated 1
INSR insulin receptor
INVS inversin
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ISL1 ISL LIM homeobox 1
KL klotho
KMT2B lysine (K)-specific methyltransferase 2B
LEP leptin
LEPR leptin receptor
LIPE lipase, hormone-sensitive
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MEN1 multiple endocrine neoplasia I
MGMT O-6-methylguanine-DNA methyltransferase
MIR184 microRNA 184
MIR375 microRNA 375
MNX1 motor neuron and pancreas homeobox 1
MPG N-methylpurine-DNA glycosylase
MUT methylmalonyl CoA mutase
MYD88 myeloid differentiation primary response 88
NCOA5 nuclear receptor coactivator 5
NEUROD1 neuronal differentiation 1
NEUROG3 neurogenin 3
NKX2-2 NK2 homeobox 2
NKX6-1 NK6 homeobox 1
ONECUT1 one cut homeobox 1
OPRM1 opioid receptor, mu 1
OSMR oncostatin M receptor
PARG poly (ADP-ribose) glycohydrolase
PAX2 paired box 2
PAX4 paired box 4
PAX6 paired box 6
PBX1 pre-B-cell leukemia homeobox 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PDX1 pancreatic and duodenal homeobox 1
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PITPNA phosphatidylinositol transfer protein, alpha
PKD1 polycystic kidney disease 1 (autosomal dominant)
PPARG peroxisome proliferator-activated receptor gamma
PRF1 perforin 1 (pore forming protein)
PRKCD protein kinase C, delta
PRKCI protein kinase C, iota
PRLR prolactin receptor
PTF1A pancreas specific transcription factor, 1a
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTTG1 pituitary tumor-transforming 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RBM4 RNA binding motif protein 4
RBM4B RNA binding motif protein 4B
RIMS2 regulating synaptic membrane exocytosis 2
RIPPLY3 ripply transcriptional repressor 3
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPSA ribosomal protein SA
SCG5 secretogranin V
SEC23B Sec23 homolog B (S. cerevisiae)
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERTAD1 SERTA domain containing 1
SGMS1 sphingomyelin synthase 1
SH2B1 SH2B adaptor protein 1
SIDT2 SID1 transmembrane family, member 2
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SOCS7 suppressor of cytokine signaling 7
SOX9 SRY (sex determining region Y)-box 9
SPOP speckle-type POZ protein
SSTR5 somatostatin receptor 5
STAT4 signal transducer and activator of transcription 4
SYTL4 synaptotagmin-like 4
THBS1 thrombospondin 1
THRA thyroid hormone receptor, alpha
TK1 thymidine kinase 1, soluble
TLE3 transducin-like enhancer of split 3
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TNK1 tyrosine kinase, non-receptor, 1
TOP3B topoisomerase (DNA) III beta
TUB tubby bipartite transcription factor
UNC13A unc-13 homolog A (C. elegans)
VIPR1 vasoactive intestinal peptide receptor 1
WFS1 Wolfram syndrome 1 (wolframin)