abnormal pancreas secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the production and/or release of biologically active substances from pancreatic tissue (Mammalian Phenotype Ontology, MP_0002694)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002694
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Genes

125 gene mutations causing the abnormal pancreas secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACE angiotensin I converting enzyme
ADIPOQ adiponectin, C1Q and collagen domain containing
AKAP5 A kinase (PRKA) anchor protein 5
ALX3 ALX homeobox 3
ANXA7 annexin A7
AQP7 aquaporin 7
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATF4 activating transcription factor 4
ATXN2 ataxin 2
BAD BCL2-associated agonist of cell death
BGLAP bone gamma-carboxyglutamate (gla) protein
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CADPS2 Ca++-dependent secretion activator 2
CARTPT CART prepropeptide
CCDC80 coiled-coil domain containing 80
CCKAR cholecystokinin A receptor
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHGB chromogranin B
CHRM3 cholinergic receptor, muscarinic 3
CISD2 CDGSH iron sulfur domain 2
CLOCK clock circadian regulator
COL5A3 collagen, type V, alpha 3
CYB5R4 cytochrome b5 reductase 4
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase)
DPP4 dipeptidyl-peptidase 4
E2F1 E2F transcription factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ERO1LB ERO1-like beta (S. cerevisiae)
ESR2 estrogen receptor 2 (ER beta)
FAM3B family with sequence similarity 3, member B
FEM1B fem-1 homolog b (C. elegans)
FFAR1 free fatty acid receptor 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXA1 forkhead box A1
GAL galanin/GMAP prepropeptide
GAST gastrin
GCGR glucagon receptor
GCK glucokinase (hexokinase 4)
GEM GTP binding protein overexpressed in skeletal muscle
GHRL ghrelin/obestatin prepropeptide
GIPR gastric inhibitory polypeptide receptor
GJD2 gap junction protein, delta 2, 36kDa
GLIS3 GLIS family zinc finger 3
GLP1R glucagon-like peptide 1 receptor
GLUD1 glutamate dehydrogenase 1
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPER1 G protein-coupled estrogen receptor 1
GPR68 G protein-coupled receptor 68
HADH hydroxyacyl-CoA dehydrogenase
HIPK3 homeodomain interacting protein kinase 3
HMGA1 high mobility group AT-hook 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFT88 intraflagellar transport 88
IL6 interleukin 6
INS insulin
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KL klotho
KMT2B lysine (K)-specific methyltransferase 2B
LEP leptin
LEPR leptin receptor
LPIN1 lipin 1
LRP5 low density lipoprotein receptor-related protein 5
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MAPK13 mitogen-activated protein kinase 13
MAPK8 mitogen-activated protein kinase 8
MIR184 microRNA 184
MIR375 microRNA 375
NAMPT nicotinamide phosphoribosyltransferase
NKX2-2 NK2 homeobox 2
NKX6-1 NK6 homeobox 1
NNT nicotinamide nucleotide transhydrogenase
OPRM1 opioid receptor, mu 1
PASK PAS domain containing serine/threonine kinase
PAX4 paired box 4
PBX1 pre-B-cell leukemia homeobox 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDX1 pancreatic and duodenal homeobox 1
PFKM phosphofructokinase, muscle
PGR progesterone receptor
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCD protein kinase C, delta
PRLR prolactin receptor
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RIMS2 regulating synaptic membrane exocytosis 2
RNF213 ring finger protein 213
RPH3AL rabphilin 3A-like (without C2 domains)
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SAMD4A sterile alpha motif domain containing 4A
SERTAD1 SERTA domain containing 1
SGMS1 sphingomyelin synthase 1
SIDT2 SID1 transmembrane family, member 2
SIRT1 sirtuin 1
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
SNAP25 synaptosomal-associated protein, 25kDa
SOX4 SRY (sex determining region Y)-box 4
SSTR5 somatostatin receptor 5
STAT4 signal transducer and activator of transcription 4
STXBP3 syntaxin binding protein 3
SYTL1 synaptotagmin-like 1
SYTL4 synaptotagmin-like 4
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
THRA thyroid hormone receptor, alpha
TLR2 toll-like receptor 2
TRH thyrotropin-releasing hormone
UCN3 urocortin 3
UNC13A unc-13 homolog A (C. elegans)
VAMP8 vesicle-associated membrane protein 8
WFS1 Wolfram syndrome 1 (wolframin)