abnormal palatal shelf fusion at midline Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages (Mammalian Phenotype Ontology, MP_0009887)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009887
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Genes

55 gene mutations causing the abnormal palatal shelf fusion at midline phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APAF1 apoptotic peptidase activating factor 1
BMP7 bone morphogenetic protein 7
BNC2 basonuclin 2
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHRD chordin
CHUK conserved helix-loop-helix ubiquitous kinase
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DHCR7 7-dehydrocholesterol reductase
FGFR2 fibroblast growth factor receptor 2
FLNA filamin A, alpha
FOXE1 forkhead box E1
FOXF2 forkhead box F2
FRAS1 Fraser extracellular matrix complex subunit 1
GAB1 GRB2-associated binding protein 1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GLI2 GLI family zinc finger 2
GRB2 growth factor receptor-bound protein 2
GSK3B glycogen synthase kinase 3 beta
HAND2 heart and neural crest derivatives expressed 2
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa
ITGAV integrin, alpha V
ITGB8 integrin, beta 8
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LHX8 LIM homeobox 8
LUZP1 leucine zipper protein 1
MN1 meningioma (disrupted in balanced translocation) 1
MSX1 msh homeobox 1
NCOA6 nuclear receptor coactivator 6
OSR2 odd-skipped related transciption factor 2
PAK1IP1 PAK1 interacting protein 1
PAX9 paired box 9
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDS5A PDS5 cohesin associated factor A
PDS5B PDS5 cohesin associated factor B
PHC1 polyhomeotic homolog 1 (Drosophila)
PRRX1 paired related homeobox 1
RSPO2 R-spondin 2
RUNX2 runt-related transcription factor 2
SATB2 SATB homeobox 2
SCHIP1 schwannomin interacting protein 1
SGPL1 sphingosine-1-phosphate lyase 1
SHOX2 short stature homeobox 2
SNAI2 snail family zinc finger 2
SOX11 SRY (sex determining region Y)-box 11
SOX5 SRY (sex determining region Y)-box 5
TBX1 T-box 1
TBX3 T-box 3
TCOF1 Treacher Collins-Franceschetti syndrome 1
TGFB3 transforming growth factor, beta 3
TSHZ1 teashirt zinc finger homeobox 1
WDR19 WD repeat domain 19
ZEB1 zinc finger E-box binding homeobox 1