abnormal palatal rugae morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly in the series of transverse folds (ridges) of the mucosa located on the anterior third part of the secondary (hard) palate of most mammalian species; rugae are present on each side of the median palatal raphe and behind the incisive papillae, but their number and arrangement are species specific; together with the teeth and the tongue, rugae take part in mastication by helping to sense, hold and mash the food; rugae harbor various types of intraepithelial sensory structures (such as Merckel cells, corpuscular endings and free nerve endings), and play a sensory role when the food is pressed by the tongue against the hard palate (Mammalian Phenotype Ontology, MP_0009652)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009652
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7 gene mutations causing the abnormal palatal rugae morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CHD7 chromodomain helicase DNA binding protein 7
EDA ectodysplasin A
EDNRB endothelin receptor type B
FGF10 fibroblast growth factor 10
FGFR2 fibroblast growth factor receptor 2
SOSTDC1 sclerostin domain containing 1
TBX22 T-box 22