abnormal ovarian follicle morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the sac-like structure in the ovary which surrounds an ovum (Mammalian Phenotype Ontology, MP_0001131)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001131
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Genes

161 gene mutations causing the abnormal ovarian follicle morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVR2A activin A receptor, type IIA
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADRM1 adhesion regulating molecule 1
AHR aryl hydrocarbon receptor
AKT2 v-akt murine thymoma viral oncogene homolog 2
AMBP alpha-1-microglobulin/bikunin precursor
AMH anti-Mullerian hormone
APC adenomatous polyposis coli
ARID5B AT rich interactive domain 5B (MRF1-like)
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BMP15 bone morphogenetic protein 15
BMPR1B bone morphogenetic protein receptor, type IB
BRCA2 breast cancer 2, early onset
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBS cystathionine-beta-synthase
CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough
CCDC79 coiled-coil domain containing 79
CCND2 cyclin D2
CCS copper chaperone for superoxide dismutase
CDK2 cyclin-dependent kinase 2
CDK6 cyclin-dependent kinase 6
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CGA glycoprotein hormones, alpha polypeptide
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CSF1 colony stimulating factor 1 (macrophage)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DAZ2 deleted in azoospermia 2
DAZAP1 DAZ associated protein 1
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DMC1 DNA meiotic recombinase 1
DMRTA1 DMRT-like family A1
EGR1 early growth response 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EWSR1 EWS RNA-binding protein 1
FADS2 fatty acid desaturase 2
FANCA Fanconi anemia, complementation group A
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FANCG Fanconi anemia, complementation group G
FANCL Fanconi anemia, complementation group L
FANCM Fanconi anemia, complementation group M
FIGLA folliculogenesis specific basic helix-loop-helix
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXC1 forkhead box C1
FOXL2 forkhead box L2
FOXO3 forkhead box O3
FSHB follicle stimulating hormone, beta polypeptide
FSHR follicle stimulating hormone receptor
FST follistatin
FZD1 frizzled class receptor 1
GADD45G growth arrest and DNA-damage-inducible, gamma
GDF9 growth differentiation factor 9
GGT1 gamma-glutamyltransferase 1
GHR growth hormone receptor
GJA1 gap junction protein, alpha 1, 43kDa
GJA4 gap junction protein, alpha 4, 37kDa
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GNRHR gonadotropin-releasing hormone receptor
GPR149 G protein-coupled receptor 149
HELQ helicase, POLQ-like
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)
HSF2 heat shock transcription factor 2
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
INHA inhibin, alpha
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
KL klotho
KPNA1 karyopherin alpha 1 (importin alpha 5)
LATS1 large tumor suppressor kinase 1
LEP leptin
LEPR leptin receptor
LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
LHB luteinizing hormone beta polypeptide
LHCGR luteinizing hormone/choriogonadotropin receptor
LIN28A lin-28 homolog A (C. elegans)
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MCM8 minichromosome maintenance complex component 8
MCM9 minichromosome maintenance complex component 9
MCPH1 microcephalin 1
MEI4 meiosis-specific 4 homolog (S. cerevisiae)
MLH1 mutL homolog 1
MSH5 mutS homolog 5
NBN nibrin
NHLH2 nescient helix loop helix 2
NOBOX NOBOX oogenesis homeobox
NPC1 Niemann-Pick disease, type C1
NR0B1 nuclear receptor subfamily 0, group B, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OTX1 orthodenticle homeobox 1
PABPC1L poly(A) binding protein, cytoplasmic 1-like
PCSK6 proprotein convertase subtilisin/kexin type 6
PCYT1B phosphate cytidylyltransferase 1, choline, beta
PGR progesterone receptor
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PRDM9 PR domain containing 9
PRLR prolactin receptor
PROKR2 prokineticin receptor 2
PROP1 PROP paired-like homeobox 1
PSMC3IP PSMC3 interacting protein
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTH2 parathyroid hormone 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTX3 pentraxin 3, long
RAD21L1 RAD21-like 1 (S. pombe)
RANBP9 RAN binding protein 9
REC8 REC8 meiotic recombination protein
RSPO1 R-spondin 1
SAFB scaffold attachment factor B
SELENBP1 selenium binding protein 1
SGPL1 sphingosine-1-phosphate lyase 1
SH2B1 SH2B adaptor protein 1
SLX4 SLX4 structure-specific endonuclease subunit
SMC1B structural maintenance of chromosomes 1B
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SOD1 superoxide dismutase 1, soluble
SOX3 SRY (sex determining region Y)-box 3
SPATA22 spermatogenesis associated 22
SPO11 SPO11 meiotic protein covalently bound to DSB
SRY sex determining region Y
STAR steroidogenic acute regulatory protein
STRA8 stimulated by retinoic acid 8
SUN1 Sad1 and UNC84 domain containing 1
SYCE1 synaptonemal complex central element protein 1
SYCE3 synaptonemal complex central element protein 3
SYCP1 synaptonemal complex protein 1
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TBPL2 TATA box binding protein like 2
TEX12 testis expressed 12
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TP73 tumor protein p73
TRIP13 thyroid hormone receptor interactor 13
UBB ubiquitin B
UBE3A ubiquitin protein ligase E3A
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VGF VGF nerve growth factor inducible
WWOX WW domain containing oxidoreductase
YBX2 Y box binding protein 2
ZC3HC1 zinc finger, C3HC-type containing 1
ZFX zinc finger protein, X-linked
ZGLP1 zinc finger, GATA-like protein 1
ZP1 zona pellucida glycoprotein 1 (sperm receptor)
ZP2 zona pellucida glycoprotein 2 (sperm receptor)
ZP3 zona pellucida glycoprotein 3 (sperm receptor)