abnormal neuronal migration Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality resulting from an anomaly of neuronal migration, i.e., of the process by which neurons travel from their origin to their final position in the brain. (Human Phenotype Ontology, HP_0002269)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0006009
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Genes

86 gene mutations causing the abnormal neuronal migration phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
APAF1 apoptotic peptidase activating factor 1
APC2 adenomatosis polyposis coli 2
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARX aristaless related homeobox
ASCL1 achaete-scute family bHLH transcription factor 1
ASS1 argininosuccinate synthase 1
ASTN1 astrotactin 1
CADPS2 Ca++-dependent secretion activator 2
CCDC88A coiled-coil domain containing 88A
CCKAR cholecystokinin A receptor
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CEND1 cell cycle exit and neuronal differentiation 1
CNTNAP2 contactin associated protein-like 2
CRMP1 collapsin response mediator protein 1
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DGCR8 DGCR8 microprocessor complex subunit
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EFNA5 ephrin-A5
EGR2 early growth response 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FBXO45 F-box protein 45
FEZF1 FEZ family zinc finger 1
FGF13 fibroblast growth factor 13
FGF2 fibroblast growth factor 2 (basic)
FKRP fukutin related protein
FKTN fukutin
FLRT2 fibronectin leucine rich transmembrane protein 2
GFRA3 GDNF family receptor alpha 3
GLI3 GLI family zinc finger 3
GNPAT glyceronephosphate O-acyltransferase
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
KAT6B K(lysine) acetyltransferase 6B
KIF14 kinesin family member 14
KIF2A kinesin heavy chain member 2A
LHX5 LIM homeobox 5
LHX6 LIM homeobox 6
LMNB1 lamin B1
LMNB2 lamin B2
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MBOAT7 membrane bound O-acyltransferase domain containing 7
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1
MYH10 myosin, heavy chain 10, non-muscle
NDE1 nudE neurodevelopment protein 1
NEUROG2 neurogenin 2
NRP1 neuropilin 1
NRP2 neuropilin 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLIG2 oligodendrocyte lineage transcription factor 2
OLIG3 oligodendrocyte transcription factor 3
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PEX7 peroxisomal biogenesis factor 7
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PITX2 paired-like homeodomain 2
PLAUR plasminogen activator, urokinase receptor
PLXNA2 plexin A2
PLXNB2 plexin B2
PLXNC1 plexin C1
POMK protein-O-mannose kinase
PSEN1 presenilin 1
RELN reelin
RNF7 ring finger protein 7
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SDCCAG8 serologically defined colon cancer antigen 8
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SIM1 single-minded family bHLH transcription factor 1
SOX1 SRY (sex determining region Y)-box 1
STK25 serine/threonine kinase 25
TOP2B topoisomerase (DNA) II beta 180kDa
TP53BP2 tumor protein p53 binding protein 2
TRIO trio Rho guanine nucleotide exchange factor
TUBA1A tubulin, alpha 1a
UNC5C unc-5 homolog C (C. elegans)
UNC5D unc-5 homolog D (C. elegans)
VEGFA vascular endothelial growth factor A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB18 zinc finger and BTB domain containing 18