abnormal neurohypophysis development Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description aberrant formation or incomplete differentiation of the posterior lobe of the pituitary gland which develops as a neurohypophyseal bud, a depression in the neuroectoderm of the floor of the hypothalamus; the infundibulum, another diverticulum from the inferior aspect of the diencephalon, develops as an outgrowth of the neurohypophyseal bud and connects the neurohypophysis to the hypothalamus; the neurohypophysis develops as the infundibulum grows inferiorly from the diencephalon to meet the developing adenohypophysis (anterior pituitary lobe); the fully developed neurohypophysis consists of the infundibulum and the pars nervosa; the neural connection between the hypothalamus and pars nervosa is through the hypothalamohypophyseal tract that develops within the infundibulum (Mammalian Phenotype Ontology, MP_0013338)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0013338
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2 gene mutations causing the abnormal neurohypophysis development phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
FGF10 fibroblast growth factor 10
NKX2-1 NK2 homeobox 1