abnormal neural crest cell delamination Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the process by which a neural crest cell (NCC) physically dissociates from the neuroepithelium in the dorsal aspect of the neural tube; premigratory NCCs exist within a fully polarized epithelial layer, adjoined by adherens junctions and tight junctions; NCC delamination involves an epithelial-mesenchymal transition (EMT) during which epithelial cells are converted into migratory mesenchymal cells; EMT requires loss of apical-basal cell polarity and dissolution of tight junctions and is accompanied by changes in cytoskeletal organization and a switch in adhesive properties so that cells can separate from the neuroepithelium and emigrate (Mammalian Phenotype Ontology, MP_0012746)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0012746
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3 gene mutations causing the abnormal neural crest cell delamination phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CFL1 cofilin 1 (non-muscle)
OVOL2 ovo-like zinc finger 2
ZEB2 zinc finger E-box binding homeobox 2