abnormal myeloblast morphology/development Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the cells found in the bone marrow that give rise to the granulocyte line of blood cells (Mammalian Phenotype Ontology, MP_0002414)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002414
Similar Terms
Downloads & Tools

Genes

113 gene mutations causing the abnormal myeloblast morphology/development phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACVR2A activin A receptor, type IIA
ALOX15 arachidonate 15-lipoxygenase
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARID4A AT rich interactive domain 4A (RBP1-like)
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
ATP7B ATPase, Cu++ transporting, beta polypeptide
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
C3AR1 complement component 3a receptor 1
CBFB core-binding factor, beta subunit
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL11 chemokine (C-C motif) ligand 11
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR4 chemokine (C-C motif) receptor 4
CD34 CD34 molecule
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal)
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CISH cytokine inducible SH2-containing protein
CPA3 carboxypeptidase A3 (mast cell)
CSF1R colony stimulating factor 1 receptor
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTSE cathepsin E
EP300 E1A binding protein p300
EPX eosinophil peroxidase
FAS Fas cell surface death receptor
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGF2 fibroblast growth factor 2 (basic)
FOXN1 forkhead box N1
FOXP3 forkhead box P3
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FZD9 frizzled class receptor 9
GADD45A growth arrest and DNA-damage-inducible, alpha
GALC galactosylceramidase
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GATA1 GATA binding protein 1 (globin transcription factor 1)
GFI1 growth factor independent 1 transcription repressor
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPC2 glypican 2
GPRC5C G protein-coupled receptor, class C, group 5, member C
HCK HCK proto-oncogene, Src family tyrosine kinase
HHEX hematopoietically expressed homeobox
ICAM1 intercellular adhesion molecule 1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL17RB interleukin 17 receptor B
IL1R1 interleukin 1 receptor, type I
IL1RL1 interleukin 1 receptor-like 1
IL21R interleukin 21 receptor
IL25 interleukin 25
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB7 integrin, beta 7
KISS1R KISS1 receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KMT2E lysine (K)-specific methyltransferase 2E
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LBR lamin B receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LIF leukemia inhibitory factor
LTB4R leukotriene B4 receptor
LYN LYN proto-oncogene, Src family tyrosine kinase
LYST lysosomal trafficking regulator
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MECOM MDS1 and EVI1 complex locus
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MINA MYC induced nuclear antigen
MIR223 microRNA 223
MMP9 matrix metallopeptidase 9
MYB v-myb avian myeloblastosis viral oncogene homolog
NOS2 nitric oxide synthase 2, inducible
NQO1 NAD(P)H dehydrogenase, quinone 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLA2G10 phospholipase A2, group X
PLSCR1 phospholipid scramblase 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTGDR2 prostaglandin D2 receptor 2
RAG1 recombination activating gene 1
RB1 retinoblastoma 1
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SENP1 SUMO1/sentrin specific peptidase 1
SH2B3 SH2B adaptor protein 3
SHARPIN SHANK-associated RH domain interactor
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SOCS1 suppressor of cytokine signaling 1
SPI1 Spi-1 proto-oncogene
SPRED1 sprouty-related, EVH1 domain containing 1
TBK1 TANK-binding kinase 1
TET2 tet methylcytosine dioxygenase 2
THBS1 thrombospondin 1
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast)
TRIB1 tribbles pseudokinase 1