abnormal mitotic spindle morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis (Mammalian Phenotype Ontology, MP_0009760)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009760
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Genes

22 gene mutations causing the abnormal mitotic spindle morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AURKA aurora kinase A
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CENPJ centromere protein J
CTNND1 catenin (cadherin-associated protein), delta 1
EYA1 EYA transcriptional coactivator and phosphatase 1
FBXO5 F-box protein 5
LATS1 large tumor suppressor kinase 1
MAGOH mago-nashi homolog, proliferation-associated (Drosophila)
MASTL microtubule associated serine/threonine kinase-like
MCPH1 microcephalin 1
NUSAP1 nucleolar and spindle associated protein 1
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PLK1 polo-like kinase 1
PRICKLE1 prickle homolog 1 (Drosophila)
TPX2 TPX2, microtubule-associated
TUBG1 tubulin, gamma 1
USP44 ubiquitin specific peptidase 44