abnormal mesoderm development Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description failure or abnormality in the formation of the middle of the three primary germ layers of the embryo (the others being ectoderm and endoderm) during gastrulation; mesoderm is the origin of connective tissues, myoblasts, blood, the cardiovascular and lymphatic systems, most of the urogenital system, and the lining of the pericardial, pleural, and peritoneal cavities (Mammalian Phenotype Ontology, MP_0001680)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001680
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Genes

136 gene mutations causing the abnormal mesoderm development phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
ADAM10 ADAM metallopeptidase domain 10
AMN amnion associated transmembrane protein
APC adenomatous polyposis coli
APH1A APH1A gamma secretase subunit
ARC activity-regulated cytoskeleton-associated protein
ARID1A AT rich interactive domain 1A (SWI-like)
AXIN1 axin 1
BMP4 bone morphogenetic protein 4
BMP5 bone morphogenetic protein 5
BMPR1A bone morphogenetic protein receptor, type IA
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BPTF bromodomain PHD finger transcription factor
BRCA1 breast cancer 1, early onset
CHD8 chromodomain helicase DNA binding protein 8
CHRD chordin
CLUAP1 clusterin associated protein 1
COL2A1 collagen, type II, alpha 1
COPS3 COP9 signalosome subunit 3
CRB2 crumbs family member 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DACT1 dishevelled-binding antagonist of beta-catenin 1
DAD1 defender against cell death 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DLL1 delta-like 1 (Drosophila)
DLL3 delta-like 3 (Drosophila)
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
ECSIT ECSIT signalling integrator
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELF5 E74-like factor 5 (ets domain transcription factor)
EOMES eomesodermin
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPHA2 EPH receptor A2
EXOC4 exocyst complex component 4
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR1 fibroblast growth factor receptor 1
FN1 fibronectin 1
FOXA2 forkhead box A2
FOXD3 forkhead box D3
FOXF1 forkhead box F1
FOXH1 forkhead box H1
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GDF3 growth differentiation factor 3
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1
HAND1 heart and neural crest derivatives expressed 1
HIRA histone cell cycle regulator
HNF4A hepatocyte nuclear factor 4, alpha
IFT172 intraflagellar transport 172
ISL1 ISL LIM homeobox 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KAT2A K(lysine) acetyltransferase 2A
KIF3A kinesin family member 3A
KMT2A lysine (K)-specific methyltransferase 2A
LHX1 LIM homeobox 1
LRP6 low density lipoprotein receptor-related protein 6
MACF1 microtubule-actin crosslinking factor 1
MECOM MDS1 and EVI1 complex locus
MESDC2 mesoderm development candidate 2
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2
METAP2 methionyl aminopeptidase 2
MIB1 mindbomb E3 ubiquitin protein ligase 1
MIXL1 Mix paired-like homeobox
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MSGN1 mesogenin 1
MYL1 myosin, light chain 1, alkali; skeletal, fast
NCKAP1 NCK-associated protein 1
NF2 neurofibromin 2 (merlin)
NFE2L1 nuclear factor, erythroid 2-like 1
NODAL nodal growth differentiation factor
NR5A2 nuclear receptor subfamily 5, group A, member 2
NSD1 nuclear receptor binding SET domain protein 1
NUP133 nucleoporin 133kDa
OTX2 orthodenticle homeobox 2
PALB2 partner and localizer of BRCA2
PAX2 paired box 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PITX2 paired-like homeodomain 2
PKNOX1 PBX/knotted 1 homeobox 1
POGLUT1 protein O-glucosyltransferase 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R8 protein phosphatase 1, regulatory subunit 8
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRICKLE1 prickle homolog 1 (Drosophila)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCI protein kinase C, iota
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD51 RAD51 recombinase
RANGAP1 Ran GTPase activating protein 1
RDH10 retinol dehydrogenase 10 (all-trans)
RNF2 ring finger protein 2
RTEL1 regulator of telomere elongation helicase 1
SALL4 spalt-like transcription factor 4
SKI SKI proto-oncogene
SLC31A1 solute carrier family 31 (copper transporter), member 1
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SNAI1 snail family zinc finger 1
SRF serum response factor (c-fos serum response element-binding transcription factor)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
T T, brachyury homolog (mouse)
TBX6 T-box 6
TCF15 transcription factor 15 (basic helix-loop-helix)
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TDGF1 teratocarcinoma-derived growth factor 1
TENM4 teneurin transmembrane protein 4
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TJP2 tight junction protein 2
TLN1 talin 1
TPT1 tumor protein, translationally-controlled 1
TRIM28 tripartite motif containing 28
TRIM33 tripartite motif containing 33
TSG101 tumor susceptibility 101
TSIX TSIX transcript, XIST antisense RNA
UGDH UDP-glucose 6-dehydrogenase
UHRF1 ubiquitin-like with PHD and ring finger domains 1
VCL vinculin
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WASL Wiskott-Aldrich syndrome-like
WLS wntless Wnt ligand secretion mediator
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A
WNT5A wingless-type MMTV integration site family, member 5A
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZIC3 Zic family member 3