abnormal mesangial cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the modified smooth muscle cells that are interposed between endothelial cells and the basement membrane in the central or stalk region of the capillary tuft of the renal glomerulus, which regulate blood flow by their contractile activity, and secrete extracellular matrix, prostaglandins, and cytokines; mesangial cells also have phagocytic activity, removing proteins and other molecules trapped in the glomerular basement membrane or filtration barrier (Mammalian Phenotype Ontology, MP_0005327)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005327
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Genes

34 gene mutations causing the abnormal mesangial cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
CD151 CD151 molecule (Raph blood group)
CD2AP CD2-associated protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFH complement factor H
CLU clusterin
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A5 collagen, type IV, alpha 5
FAS Fas cell surface death receptor
FOXC2 forkhead box C2
GADD45A growth arrest and DNA-damage-inducible, alpha
GDNF glial cell derived neurotrophic factor
GPR4 G protein-coupled receptor 4
HPRT1 hypoxanthine phosphoribosyltransferase 1
KIRREL kin of IRRE like (Drosophila)
LAMA5 laminin, alpha 5
LCAT lecithin-cholesterol acyltransferase
LYN LYN proto-oncogene, Src family tyrosine kinase
MARK2 MAP/microtubule affinity-regulating kinase 2
MTA2 metastasis associated 1 family, member 2
NFE2L2 nuclear factor, erythroid 2-like 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH2 notch 2
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
PDGFB platelet-derived growth factor beta polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PKN1 protein kinase N1
SYK spleen tyrosine kinase
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRAF3IP2 TRAF3 interacting protein 2
VEGFA vascular endothelial growth factor A
WAS Wiskott-Aldrich syndrome
WT1 Wilms tumor 1