abnormal lymph node secondary follicle morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of a lymph node primary follicle that has undergone antigenic challenge and is characterized by a ring of concentrically packed B lymphocytes surrounding a germinal center, which contains proliferating B cells, and a mantle area that contains nondividing B cells and some helper T cells with macrophages and follicular dendritic cells interspersed (Mammalian Phenotype Ontology, MP_0002346)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002346
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Genes

22 gene mutations causing the abnormal lymph node secondary follicle morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BTK Bruton agammaglobulinemia tyrosine kinase
CCR7 chemokine (C-C motif) receptor 7
CD37 CD37 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CXCL13 chemokine (C-X-C motif) ligand 13
HR hair growth associated
IRF4 interferon regulatory factor 4
KLHL6 kelch-like family member 6
LAT linker for activation of T cells
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
POU2AF1 POU class 2 associating factor 1
PRKCD protein kinase C, delta
RC3H1 ring finger and CCCH-type domains 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
TNF tumor necrosis factor
TRAF2 TNF receptor-associated factor 2
UNC13D unc-13 homolog D (C. elegans)