abnormal lung-associated mesenchyme development Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description abnormality in the formation of the lung tissue comprised of multiple cell types (including connective tissue, endothelial cells, lymphatics, smooth muscle cells surrounding airways and blood vessels, myofibroblasts involved in septum formation, and cartilage-forming cells in the trachea), with most cells thought to be derived from the splanchnic mesenchyme, and other cells (endothelial, smooth muscle) believed to invade the lung as it expands; lung mesenchyme is a critical determinant of the shape and size of the developing lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung (Mammalian Phenotype Ontology, MP_0011142)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011142
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Genes

3 gene mutations causing the abnormal lung-associated mesenchyme development phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
FGF9 fibroblast growth factor 9
HOPX HOP homeobox
WNT2 wingless-type MMTV integration site family member 2