abnormal liver triglyceride level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description aberrant concentration of naturally occurring esters of three fatty acids and glycerol in the liver; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liverower than normal concentration of triacylglycerols in the liver (Mammalian Phenotype Ontology, MP_0012778)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0012778
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Genes

110 gene mutations causing the abnormal liver triglyceride level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABHD5 abhydrolase domain containing 5
ACOT13 acyl-CoA thioesterase 13
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGRP agouti related neuropeptide
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
APOC1 apolipoprotein C-I
BCO2 beta-carotene oxygenase 2
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD36 CD36 molecule (thrombospondin receptor)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CES1 carboxylesterase 1
CHKA choline kinase alpha
CRBN cereblon
CXCL14 chemokine (C-X-C motif) ligand 14
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DGAT1 diacylglycerol O-acyltransferase 1
EGR1 early growth response 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERCC1 excision repair cross-complementation group 1
FABP1 fatty acid binding protein 1, liver
FADS2 fatty acid desaturase 2
FFAR1 free fatty acid receptor 1
FFAR4 free fatty acid receptor 4
FGF21 fibroblast growth factor 21
FGL1 fibrinogen-like 1
FOXA2 forkhead box A2
FOXO1 forkhead box O1
G0S2 G0/G1 switch 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GPR12 G protein-coupled receptor 12
GPRC6A G protein-coupled receptor, class C, group 6, member A
GUCY2C guanylate cyclase 2C
GYS2 glycogen synthase 2 (liver)
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HRH1 histamine receptor H1
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
IL10 interleukin 10
INS insulin
JUND jun D proto-oncogene
KMT2B lysine (K)-specific methyltransferase 2B
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPE lipase, hormone-sensitive
LIPI lipase, member I
LPIN1 lipin 1
LRP6 low density lipoprotein receptor-related protein 6
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MC4R melanocortin 4 receptor
MECP2 methyl CpG binding protein 2
MGLL monoglyceride lipase
MIR122 microRNA 122
MTTP microsomal triglyceride transfer protein
NCOA3 nuclear receptor coactivator 3
NCOA5 nuclear receptor coactivator 5
NEGR1 neuronal growth regulator 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR2C2 nuclear receptor subfamily 2, group C, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
PANK1 pantothenate kinase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEX11A peroxisomal biogenesis factor 11 alpha
PLIN2 perilipin 2
PLIN5 perilipin 5
PNPLA2 patatin-like phospholipase domain containing 2
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRLH prolactin releasing hormone
PROX1 prospero homeobox 1
RETN resistin
RGN regucalcin
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCP2 sterol carrier protein 2
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SESN2 sestrin 2
SIK3 SIK family kinase 3
SIRT3 sirtuin 3
SIRT7 sirtuin 7
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10
SOCS2 suppressor of cytokine signaling 2
SRA1 steroid receptor RNA activator 1
SREBF1 sterol regulatory element binding transcription factor 1
SSFA2 sperm specific antigen 2
STARD10 StAR-related lipid transfer (START) domain containing 10
STEAP4 STEAP family member 4
TLR4 toll-like receptor 4