abnormal liver lobule morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein (Mammalian Phenotype Ontology, MP_0008987)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008987
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Genes

135 gene mutations causing the abnormal liver lobule morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACOX1 acyl-CoA oxidase 1, palmitoyl
ACVRL1 activin A receptor type II-like 1
ADA adenosine deaminase
AHR aryl hydrocarbon receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALMS1 Alstrom syndrome protein 1
ARG1 arginase 1
ARSG arylsulfatase G
ATF4 activating transcription factor 4
ATG5 autophagy related 5
ATP7B ATPase, Cu++ transporting, beta polypeptide
BIN3 bridging integrator 3
BIRC6 baculoviral IAP repeat containing 6
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1
BRD4 bromodomain containing 4
CBS cystathionine-beta-synthase
CCR1 chemokine (C-C motif) receptor 1
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLCA2 chloride channel accessory 2
CLN3 ceroid-lipofuscinosis, neuronal 3
CP ceruloplasmin (ferroxidase)
CRH corticotropin releasing hormone
CSF1 colony stimulating factor 1 (macrophage)
CTBS chitobiase, di-N-acetyl-
CTHRC1 collagen triple helix repeat containing 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
EGFR epidermal growth factor receptor
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERCC1 excision repair cross-complementation group 1
ERCC5 excision repair cross-complementation group 5
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FOXM1 forkhead box M1
FOXP3 forkhead box P3
GLB1 galactosidase, beta 1
GLMP glycosylated lysosomal membrane protein
GNMT glycine N-methyltransferase
GOLM1 golgi membrane protein 1
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GRN granulin
GSK3B glycogen synthase kinase 3 beta
GSTZ1 glutathione S-transferase zeta 1
GTF2IRD1 GTF2I repeat domain containing 1
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HEXA hexosaminidase A (alpha polypeptide)
HEXB hexosaminidase B (beta polypeptide)
HFE2 hemochromatosis type 2 (juvenile)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHEX hematopoietically expressed homeobox
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HNF1A HNF1 homeobox A
HR hair growth associated
HSPG2 heparan sulfate proteoglycan 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IQGAP2 IQ motif containing GTPase activating protein 2
JAK1 Janus kinase 1
JARID2 jumonji, AT rich interactive domain 2
JUN jun proto-oncogene
KMT2B lysine (K)-specific methyltransferase 2B
KRT8 keratin 8, type II
LIF leukemia inhibitory factor
LIPA lipase A, lysosomal acid, cholesterol esterase
LRP1 low density lipoprotein receptor-related protein 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAN2C1 mannosidase, alpha, class 2C, member 1
MANBA mannosidase, beta A, lysosomal
MAP2K4 mitogen-activated protein kinase kinase 4
MDK midkine (neurite growth-promoting factor 2)
MED1 mediator complex subunit 1
MET MET proto-oncogene, receptor tyrosine kinase
MIR122 microRNA 122
MPV17 MpV17 mitochondrial inner membrane protein
MST1 macrophage stimulating 1
MTF1 metal-regulatory transcription factor 1
MUT methylmalonyl CoA mutase
MYB v-myb avian myeloblastosis viral oncogene homolog
NAGLU N-acetylglucosaminidase, alpha
NCOA6 nuclear receptor coactivator 6
NCOR1 nuclear receptor corepressor 1
NEU1 sialidase 1 (lysosomal sialidase)
NGFR nerve growth factor receptor
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
PCTP phosphatidylcholine transfer protein
PEMT phosphatidylethanolamine N-methyltransferase
PEX11A peroxisomal biogenesis factor 11 alpha
PHIP pleckstrin homology domain interacting protein
PITPNA phosphatidylinositol transfer protein, alpha
PKD1 polycystic kidney disease 1 (autosomal dominant)
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit
PROS1 protein S (alpha)
PSAP prosaposin
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
RB1CC1 RB1-inducible coiled-coil 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGN regucalcin
RPS6 ribosomal protein S6
RTN4RL1 reticulon 4 receptor-like 1
SCP2 sterol carrier protein 2
SIK3 SIK family kinase 3
SIRT7 sirtuin 7
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SOD2 superoxide dismutase 2, mitochondrial
SPTA1 spectrin, alpha, erythrocytic 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
THEM4 thioesterase superfamily member 4
TIMP3 TIMP metallopeptidase inhibitor 3
TK2 thymidine kinase 2, mitochondrial
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TSC1 tuberous sclerosis 1
TTC7A tetratricopeptide repeat domain 7A
TWIST2 twist family bHLH transcription factor 2
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
VTI1B vesicle transport through interaction with t-SNAREs 1B
WASF1 WAS protein family, member 1
ZDHHC13 zinc finger, DHHC-type containing 13