abnormal lens development Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description aberrant formation of the transparent structure of the eye responsible for focusing light rays (Mammalian Phenotype Ontology, MP_0005545)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005545
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Genes

53 gene mutations causing the abnormal lens development phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABI2 abl-interactor 2
ADAM17 ADAM metallopeptidase domain 17
BCAR3 breast cancer anti-estrogen resistance 3
BMP4 bone morphogenetic protein 4
BMP7 bone morphogenetic protein 7
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CRYAA crystallin, alpha A
CRYGA crystallin, gamma A
CRYGD crystallin, gamma D
CSK c-src tyrosine kinase
EGFR epidermal growth factor receptor
FBXO47 F-box protein 47
FGF10 fibroblast growth factor 10
FGF9 fibroblast growth factor 9
FOXE3 forkhead box E3
GJA8 gap junction protein, alpha 8, 50kDa
GJE1 gap junction protein, epsilon 1, 23kDa
GPR161 G protein-coupled receptor 161
GRIP1 glutamate receptor interacting protein 1
LHX2 LIM homeobox 2
LIM2 lens intrinsic membrane protein 2, 19kDa
MAB21L1 mab-21-like 1 (C. elegans)
MAB21L2 mab-21-like 2 (C. elegans)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MED1 mediator complex subunit 1
MIP major intrinsic protein of lens fiber
MITF microphthalmia-associated transcription factor
MSX2 msh homeobox 2
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYO10 myosin X
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies)
PAX6 paired box 6
PITX2 paired-like homeodomain 2
PITX3 paired-like homeodomain 3
PROX1 prospero homeobox 1
PXDN peroxidasin
PYGO2 pygopus family PHD finger 2
RAB23 RAB23, member RAS oncogene family
RAX retina and anterior neural fold homeobox
RB1 retinoblastoma 1
SEP15 15 kDa selenoprotein
SIRT1 sirtuin 1
SMAD2 SMAD family member 2
SOX1 SRY (sex determining region Y)-box 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB2 transforming growth factor, beta 2
VSX2 visual system homeobox 2
ZNRF3 zinc and ring finger 3