abnormal kidney interstitium morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the kidney region located between the nephrons, ureteric epithelia (ureteric tips, trunk and collecting duct system) and renal vasculature, and composed of renal support cells, including fibroblasts and macrophages, and mesenchymal stroma or interstitial cells; the renal vasculature lies within the renal interstitium but is not a part of it; various conditions can lead to scarring (fibrosis) and congestion of this area, which can cause kidney dysfunction and failure (Mammalian Phenotype Ontology, MP_0011425)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011425
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Genes

45 gene mutations causing the abnormal kidney interstitium morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AGA aspartylglucosaminidase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
APRT adenine phosphoribosyltransferase
AQP2 aquaporin 2 (collecting duct)
BCL2 B-cell CLL/lymphoma 2
CD151 CD151 molecule (Raph blood group)
CD1D CD1d molecule
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DACT3 dishevelled-binding antagonist of beta-catenin 3
DCN decorin
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GDNF glial cell derived neurotrophic factor
GLIS2 GLIS family zinc finger 2
GRHPR glyoxylate reductase/hydroxypyruvate reductase
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
INS insulin
INVS inversin
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCP kielin/chordin-like protein
LAMA5 laminin, alpha 5
LEP leptin
LGMN legumain
LIN7C lin-7 homolog C (C. elegans)
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MPV17 MpV17 mitochondrial inner membrane protein
MYO1E myosin IE
NOS3 nitric oxide synthase 3 (endothelial cell)
NPHP3 nephronophthisis 3 (adolescent)
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PKD1 polycystic kidney disease 1 (autosomal dominant)
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
REN renin
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SMAD3 SMAD family member 3
TRPS1 trichorhinophalangeal syndrome I
TRPV5 transient receptor potential cation channel, subfamily V, member 5
UMOD uromodulin
WT1 Wilms tumor 1
WWTR1 WW domain containing transcription regulator 1
XDH xanthine dehydrogenase