abnormal juxtaglomerular cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the specialized smooth muscle cells that synthesize, store, and secrete renin and are found in the wall of each afferent arteriole of a kidney glomerulus near its point of entry adjacent to a macula densa; J-G cells are distinguished by their granulated cytoplasm and play a critical role in the renin-angiotensin system and thus in renal autoregulation (Mammalian Phenotype Ontology, MP_0011300)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011300
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Genes

5 gene mutations causing the abnormal juxtaglomerular cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AGTR1 angiotensin II receptor, type 1
BDKRB2 bradykinin receptor B2
NR3C2 nuclear receptor subfamily 3, group C, member 2
REN renin
WT1 Wilms tumor 1