abnormal interleukin-12 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells (Mammalian Phenotype Ontology, MP_0008662)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008662
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Genes

52 gene mutations causing the abnormal interleukin-12 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIRE autoimmune regulator
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
CCR1 chemokine (C-C motif) receptor 1
CCR6 chemokine (C-C motif) receptor 6
CD28 CD28 molecule
CD300LF CD300 molecule-like family member f
CD36 CD36 molecule (thrombospondin receptor)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLIC4 chloride intracellular channel 4
DMD dystrophin
DUSP4 dual specificity phosphatase 4
FLT3 fms-related tyrosine kinase 3
GADD45B growth arrest and DNA-damage-inducible, beta
GPR34 G protein-coupled receptor 34
GRN granulin
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IFNG interferon, gamma
IL15 interleukin 15
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
LAT2 linker for activation of T cells family, member 2
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
MAVS mitochondrial antiviral signaling protein
MEFV Mediterranean fever
MSR1 macrophage scavenger receptor 1
MYD88 myeloid differentiation primary response 88
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
PELI1 pellino E3 ubiquitin protein ligase 1
PILRB paired immunoglobin-like type 2 receptor beta
PINK1 PTEN induced putative kinase 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIRT7 sirtuin 7
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SPP1 secreted phosphoprotein 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TLR2 toll-like receptor 2
TLR6 toll-like receptor 6
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNIP1 TNFAIP3 interacting protein 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAFD1 TRAF-type zinc finger domain containing 1
TRIB1 tribbles pseudokinase 1
TRPM2 transient receptor potential cation channel, subfamily M, member 2