abnormal interleukin-10 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation (Mammalian Phenotype Ontology, MP_0008659)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008659
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Genes

60 gene mutations causing the abnormal interleukin-10 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
CARD9 caspase recruitment domain family, member 9
CCL13 chemokine (C-C motif) ligand 13
CCR1 chemokine (C-C motif) receptor 1
CCR4 chemokine (C-C motif) receptor 4
CCR6 chemokine (C-C motif) receptor 6
CD19 CD19 molecule
CD300A CD300a molecule
CD44 CD44 molecule (Indian blood group)
CLEC4D C-type lectin domain family 4, member D
CLEC4E C-type lectin domain family 4, member E
CLEC6A C-type lectin domain family 6, member A
DUSP4 dual specificity phosphatase 4
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FLG filaggrin
FOS FBJ murine osteosarcoma viral oncogene homolog
GFI1 growth factor independent 1 transcription repressor
GPR34 G protein-coupled receptor 34
GRN granulin
HAVCR1 hepatitis A virus cellular receptor 1
ICOSLG inducible T-cell co-stimulator ligand
IFNG interferon, gamma
IL13 interleukin 13
IL13RA2 interleukin 13 receptor, alpha 2
IL17RB interleukin 17 receptor B
IL20RB interleukin 20 receptor beta
IL4 interleukin 4
IL4R interleukin 4 receptor
ITK IL2-inducible T-cell kinase
LAT2 linker for activation of T cells family, member 2
LIF leukemia inhibitory factor
LPAR2 lysophosphatidic acid receptor 2
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MEFV Mediterranean fever
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIR155 microRNA 155
MYD88 myeloid differentiation primary response 88
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
ORAI1 ORAI calcium release-activated calcium modulator 1
PELI1 pellino E3 ubiquitin protein ligase 1
PILRB paired immunoglobin-like type 2 receptor beta
PINK1 PTEN induced putative kinase 1
PRF1 perforin 1 (pore forming protein)
RGS16 regulator of G-protein signaling 16
SASH3 SAM and SH3 domain containing 3
SDC1 syndecan 1
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SPP1 secreted phosphoprotein 1
TIGIT T cell immunoreceptor with Ig and ITIM domains
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
ZC3H12D zinc finger CCCH-type containing 12D