abnormal interleukin-1 secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the production or release of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens (Mammalian Phenotype Ontology, MP_0008650)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008650
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Genes

61 gene mutations causing the abnormal interleukin-1 secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIM2 absent in melanoma 2
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BIRC3 baculoviral IAP repeat containing 3
BPIFA1 BPI fold containing family A, member 1
CASP12 caspase 12 (gene/pseudogene)
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCL13 chemokine (C-C motif) ligand 13
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD200R1 CD200 receptor 1
CD300LF CD300 molecule-like family member f
CD44 CD44 molecule (Indian blood group)
CLEC6A C-type lectin domain family 6, member A
CXCL6 chemokine (C-X-C motif) ligand 6
DRD2 dopamine receptor D2
DUSP1 dual specificity phosphatase 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
GBP5 guanylate binding protein 5
GFI1 growth factor independent 1 transcription repressor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPR65 G protein-coupled receptor 65
GRN granulin
IFNB1 interferon, beta 1, fibroblast
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL33 interleukin 33
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MBTPS1 membrane-bound transcription factor peptidase, site 1
MEFV Mediterranean fever
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MUC2 mucin 2, oligomeric mucus/gel-forming
MYD88 myeloid differentiation primary response 88
NCOA3 nuclear receptor coactivator 3
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRC4 NLR family, CARD domain containing 4
NLRP1 NLR family, pyrin domain containing 1
NLRP3 NLR family, pyrin domain containing 3
NLRX1 NLR family member X1
NOD2 nucleotide-binding oligomerization domain containing 2
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PCSK1 proprotein convertase subtilisin/kexin type 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PILRB paired immunoglobin-like type 2 receptor beta
PINK1 PTEN induced putative kinase 1
PYCARD PYD and CARD domain containing
RORA RAR-related orphan receptor A
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SOCS2 suppressor of cytokine signaling 2
SSTR4 somatostatin receptor 4
STAT1 signal transducer and activator of transcription 1, 91kDa
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZC3H12A zinc finger CCCH-type containing 12A