abnormal interferon-alpha secretion Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells (Mammalian Phenotype Ontology, MP_0008557)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008557
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Genes

24 gene mutations causing the abnormal interferon-alpha secretion phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AZI2 5-azacytidine induced 2
CXCL6 chemokine (C-X-C motif) ligand 6
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58
FLT3 fms-related tyrosine kinase 3
IFIH1 interferon induced with helicase C domain 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNAR2 interferon (alpha, beta and omega) receptor 2
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK2 interleukin-1 receptor-associated kinase 2
IRAK4 interleukin-1 receptor-associated kinase 4
IRF1 interferon regulatory factor 1
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
IRF9 interferon regulatory factor 9
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK14 mitogen-activated protein kinase 14
MAVS mitochondrial antiviral signaling protein
MYD88 myeloid differentiation primary response 88
PACSIN1 protein kinase C and casein kinase substrate in neurons 1
PELI1 pellino E3 ubiquitin protein ligase 1
RSAD2 radical S-adenosyl methionine domain containing 2
TANK TRAF family member-associated NFKB activator
TLR9 toll-like receptor 9
UNC93B1 unc-93 homolog B1 (C. elegans)