abnormal inhibitory postsynaptic currents Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization (Mammalian Phenotype Ontology, MP_0002945)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002945
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Genes

61 gene mutations causing the abnormal inhibitory postsynaptic currents phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
BDNF brain-derived neurotrophic factor
C1QA complement component 1, q subcomponent, A chain
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CAMK4 calcium/calmodulin-dependent protein kinase IV
CC2D1A coiled-coil and C2 domain containing 1A
CHRM1 cholinergic receptor, muscarinic 1
CHRM3 cholinergic receptor, muscarinic 3
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CNR1 cannabinoid receptor 1 (brain)
CNTNAP4 contactin associated protein-like 4
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
DAGLA diacylglycerol lipase, alpha
DCX doublecortin
DNM1 dynamin 1
DOC2B double C2-like domains, beta
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
ERC2 ELKS/RAB6-interacting/CAST family member 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GABRD gamma-aminobutyric acid (GABA) A receptor, delta
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GLRA1 glycine receptor, alpha 1
GLRA2 glycine receptor, alpha 2
GLRA3 glycine receptor, alpha 3
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRIK1 glutamate receptor, ionotropic, kainate 1
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2
LEPR leptin receptor
LHX6 LIM homeobox 6
NBEA neurobeachin
NLGN3 neuroligin 3
NOVA2 neuro-oncological ventral antigen 2
NPAS4 neuronal PAS domain protein 4
NRXN2 neurexin 2
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PRNP prion protein
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RIMS1 regulating synaptic membrane exocytosis 1
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SV2A synaptic vesicle glycoprotein 2A
SYN1 synapsin I
SYN3 synapsin III
SYT1 synaptotagmin I
SYT2 synaptotagmin II
SYT5 synaptotagmin V
TYROBP TYRO protein tyrosine kinase binding protein
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)