abnormal hepatocyte morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules (Mammalian Phenotype Ontology, MP_0000607)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000607
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Genes

109 gene mutations causing the abnormal hepatocyte morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACOX1 acyl-CoA oxidase 1, palmitoyl
ADA adenosine deaminase
AHR aryl hydrocarbon receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALMS1 Alstrom syndrome protein 1
ARG1 arginase 1
ARSG arylsulfatase G
ATF4 activating transcription factor 4
ATG5 autophagy related 5
ATP7B ATPase, Cu++ transporting, beta polypeptide
BIN3 bridging integrator 3
BIRC6 baculoviral IAP repeat containing 6
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1
BRD4 bromodomain containing 4
CBS cystathionine-beta-synthase
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLCA2 chloride channel accessory 2
CLN3 ceroid-lipofuscinosis, neuronal 3
CP ceruloplasmin (ferroxidase)
CRH corticotropin releasing hormone
CTHRC1 collagen triple helix repeat containing 1
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
EGFR epidermal growth factor receptor
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERCC1 excision repair cross-complementation group 1
ERCC5 excision repair cross-complementation group 5
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FOXM1 forkhead box M1
GLB1 galactosidase, beta 1
GOLM1 golgi membrane protein 1
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GRN granulin
GSK3B glycogen synthase kinase 3 beta
GSTZ1 glutathione S-transferase zeta 1
GTF2IRD1 GTF2I repeat domain containing 1
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HEXA hexosaminidase A (alpha polypeptide)
HEXB hexosaminidase B (beta polypeptide)
HFE2 hemochromatosis type 2 (juvenile)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHEX hematopoietically expressed homeobox
HMGCL 3-hydroxymethyl-3-methylglutaryl-CoA lyase
HNF1A HNF1 homeobox A
HR hair growth associated
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IQGAP2 IQ motif containing GTPase activating protein 2
JAK1 Janus kinase 1
JARID2 jumonji, AT rich interactive domain 2
JUN jun proto-oncogene
KMT2B lysine (K)-specific methyltransferase 2B
KRT8 keratin 8, type II
LIF leukemia inhibitory factor
LIPA lipase A, lysosomal acid, cholesterol esterase
LRP1 low density lipoprotein receptor-related protein 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MAN2C1 mannosidase, alpha, class 2C, member 1
MANBA mannosidase, beta A, lysosomal
MAP2K4 mitogen-activated protein kinase kinase 4
MDK midkine (neurite growth-promoting factor 2)
MPV17 MpV17 mitochondrial inner membrane protein
MST1 macrophage stimulating 1
MUT methylmalonyl CoA mutase
NAGLU N-acetylglucosaminidase, alpha
NCOA6 nuclear receptor coactivator 6
NCOR1 nuclear receptor corepressor 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NR1H4 nuclear receptor subfamily 1, group H, member 4
PEMT phosphatidylethanolamine N-methyltransferase
PEX11A peroxisomal biogenesis factor 11 alpha
PHIP pleckstrin homology domain interacting protein
PITPNA phosphatidylinositol transfer protein, alpha
PKD1 polycystic kidney disease 1 (autosomal dominant)
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PROS1 protein S (alpha)
PSAP prosaposin
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
RB1CC1 RB1-inducible coiled-coil 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RGN regucalcin
RPS6 ribosomal protein S6
RTN4RL1 reticulon 4 receptor-like 1
SCP2 sterol carrier protein 2
SIK3 SIK family kinase 3
SIRT7 sirtuin 7
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SOD2 superoxide dismutase 2, mitochondrial
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
THEM4 thioesterase superfamily member 4
TK2 thymidine kinase 2, mitochondrial
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TSC1 tuberous sclerosis 1
TTC7A tetratricopeptide repeat domain 7A
TWIST2 twist family bHLH transcription factor 2
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
VTI1B vesicle transport through interaction with t-SNAREs 1B
WASF1 WAS protein family, member 1