abnormal heart tube morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the primitive epithelial cardiac tube before the division into the chambers of the mature heart (Mammalian Phenotype Ontology, MP_0000270)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000270
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Genes

60 gene mutations causing the abnormal heart tube morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADRBK1 adrenergic, beta, receptor kinase 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
APC adenomatous polyposis coli
AXIN1 axin 1
AXIN2 axin 2
BMP10 bone morphogenetic protein 10
CCM2 cerebral cavernous malformation 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHMP5 charged multivesicular body protein 5
CRB2 crumbs family member 2
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTBP2 C-terminal binding protein 2
CXADR coxsackie virus and adenovirus receptor
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXP1 forkhead box P1
FOXP4 forkhead box P4
FURIN furin (paired basic amino acid cleaving enzyme)
GATA4 GATA binding protein 4
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HHEX hematopoietically expressed homeobox
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIRA histone cell cycle regulator
HSPG2 heparan sulfate proteoglycan 2
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1
MIXL1 Mix paired-like homeobox
MYL7 myosin, light chain 7, regulatory
NCKAP1 NCK-associated protein 1
NKX2-5 NK2 homeobox 5
NODAL nodal growth differentiation factor
NR2F2 nuclear receptor subfamily 2, group F, member 2
OVOL2 ovo-like zinc finger 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PHC1 polyhomeotic homolog 1 (Drosophila)
PKD1 polycystic kidney disease 1 (autosomal dominant)
POGLUT1 protein O-glucosyltransferase 1
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCI protein kinase C, iota
PTEN phosphatase and tensin homolog
PTPRB protein tyrosine phosphatase, receptor type, B
RDH10 retinol dehydrogenase 10 (all-trans)
RXRA retinoid X receptor, alpha
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SMAD2 SMAD family member 2
SMAD5 SMAD family member 5
SOX4 SRY (sex determining region Y)-box 4
SSR1 signal sequence receptor, alpha
T T, brachyury homolog (mouse)
TBX1 T-box 1
TBX2 T-box 2
TBX20 T-box 20
TBX5 T-box 5
TLL1 tolloid-like 1
TMOD1 tropomodulin 1
VCAN versican
WDR35 WD repeat domain 35