abnormal heart rate Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than or fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute (Mammalian Phenotype Ontology, MP_0001629)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001629
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Genes

146 gene mutations causing the abnormal heart rate phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACADVL acyl-CoA dehydrogenase, very long chain
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ADCY10 adenylate cyclase 10 (soluble)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADRA1A adrenoceptor alpha 1A
ADRA1B adrenoceptor alpha 1B
ADRA2A adrenoceptor alpha 2A
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AKAP10 A kinase (PRKA) anchor protein 10
ANK2 ankyrin 2, neuronal
ARID1A AT rich interactive domain 1A (SWI-like)
ARL6 ADP-ribosylation factor-like 6
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRB1 arrestin, beta 1
ASPH aspartate beta-hydroxylase
AVPR1A arginine vasopressin receptor 1A
BBS1 Bardet-Biedl syndrome 1
BMP10 bone morphogenetic protein 10
BRAF B-Raf proto-oncogene, serine/threonine kinase
BVES blood vessel epicardial substance
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALCB calcitonin-related polypeptide beta
CASQ2 calsequestrin 2 (cardiac muscle)
CD47 CD47 molecule
CDH23 cadherin-related 23
CHRM2 cholinergic receptor, muscarinic 2
CHRM4 cholinergic receptor, muscarinic 4
CLOCK clock circadian regulator
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DLL1 delta-like 1 (Drosophila)
DRD2 dopamine receptor D2
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
EPHA3 EPH receptor A3
FFAR3 free fatty acid receptor 3
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXP1 forkhead box P1
GBE1 glucan (1,4-alpha-), branching enzyme 1
GJA1 gap junction protein, alpha 1, 43kDa
GJA5 gap junction protein, alpha 5, 40kDa
GLA galactosidase, alpha
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HCRT hypocretin (orexin) neuropeptide precursor
HDAC2 histone deacetylase 2
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
IDUA iduronidase, alpha-L-
IER3 immediate early response 3
IGHMBP2 immunoglobulin mu binding protein 2
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JUP junction plakoglobin
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KEL Kell blood group, metallo-endopeptidase
KL klotho
LAMA4 laminin, alpha 4
LEPR leptin receptor
LHX1 LIM homeobox 1
LMNA lamin A/C
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCHR1 melanin-concentrating hormone receptor 1
MEF2A myocyte enhancer factor 2A
MGP matrix Gla protein
MPV17 MpV17 mitochondrial inner membrane protein
MRVI1 murine retrovirus integration site 1 homolog
MTA1 metastasis associated 1
MYL7 myosin, light chain 7, regulatory
NCOR1 nuclear receptor corepressor 1
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NHLH1 nescient helix loop helix 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS3 nitric oxide synthase 3 (endothelial cell)
NPAS2 neuronal PAS domain protein 2
NPPA natriuretic peptide A
NPY1R neuropeptide Y receptor Y1
NRG1 neuregulin 1
NTF3 neurotrophin 3
NUCB2 nucleobindin 2
PDC phosducin
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PNPLA2 patatin-like phospholipase domain containing 2
POPDC2 popeye domain containing 2
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTS 6-pyruvoyltetrahydropterin synthase
PZP pregnancy-zone protein
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
REN renin
RGS5 regulator of G-protein signaling 5
RGS6 regulator of G-protein signaling 6
RNLS renalase, FAD-dependent amine oxidase
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RXRA retinoid X receptor, alpha
RYR2 ryanodine receptor 2 (cardiac)
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SFRP2 secreted frizzled-related protein 2
SH3PXD2B SH3 and PX domains 2B
SHOX2 short stature homeobox 2
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SMN1 survival of motor neuron 1, telomeric
SOX4 SRY (sex determining region Y)-box 4
SP4 Sp4 transcription factor
SPP1 secreted phosphoprotein 1
SYNE1 spectrin repeat containing, nuclear envelope 1
TBX3 T-box 3
TBX5 T-box 5
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TGFB1 transforming growth factor, beta 1
TH tyrosine hydroxylase
THBS1 thrombospondin 1
THRA thyroid hormone receptor, alpha
THRB thyroid hormone receptor, beta
TPH1 tryptophan hydroxylase 1
UBE3B ubiquitin protein ligase E3B
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
ZFPM2 zinc finger protein, FOG family member 2
ZRANB2 zinc finger, RAN-binding domain containing 2