abnormal germinal center b cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen (Mammalian Phenotype Ontology, MP_0008176)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008176
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Genes

32 gene mutations causing the abnormal germinal center b cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AICDA activation-induced cytidine deaminase
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BATF basic leucine zipper transcription factor, ATF-like
BCL6 B-cell CLL/lymphoma 6
CD274 CD274 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD84 CD84 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
DOCK8 dedicator of cytokinesis 8
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
ICOS inducible T-cell co-stimulator
IL2 interleukin 2
IL21 interleukin 21
ITK IL2-inducible T-cell kinase
LTB lymphotoxin beta (TNF superfamily, member 3)
MIR155 microRNA 155
MIR210 microRNA 210
PKN1 protein kinase N1
POLB polymerase (DNA directed), beta
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RGS13 regulator of G-protein signaling 13
S1PR2 sphingosine-1-phosphate receptor 2
SH2D1A SH2 domain containing 1A
TNF tumor necrosis factor
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNIP1 TNFAIP3 interacting protein 1
TYROBP TYRO protein tyrosine kinase binding protein
WAS Wiskott-Aldrich syndrome
ZEB1 zinc finger E-box binding homeobox 1