abnormal follicular dendritic cell morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of a cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response (Mammalian Phenotype Ontology, MP_0008196)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008196
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Genes

11 gene mutations causing the abnormal follicular dendritic cell morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BCL3 B-cell CLL/lymphoma 3
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR5 chemokine (C-X-C motif) receptor 5
DOCK8 dedicator of cytokinesis 8
IGHM immunoglobulin heavy constant mu
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAP3K14 mitogen-activated protein kinase kinase kinase 14
PCSK1 proprotein convertase subtilisin/kexin type 1
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A