abnormal fat pad morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the encapsulated adipose tissue (Mammalian Phenotype Ontology, MP_0005334)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005334
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Genes

209 gene mutations causing the abnormal fat pad morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACOT13 acyl-CoA thioesterase 13
ACTB actin, beta
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR2 adiponectin receptor 2
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
ADRM1 adhesion regulating molecule 1
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR2 angiotensin II receptor, type 2
ALOX5 arachidonate 5-lipoxygenase
ANGPTL3 angiopoietin-like 3
ANXA1 annexin A1
APOE apolipoprotein E
AQP7 aquaporin 7
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARRDC3 arrestin domain containing 3
ASIP agouti signaling protein
ATF4 activating transcription factor 4
ATXN2 ataxin 2
BAG3 BCL2-associated athanogene 3
BBS1 Bardet-Biedl syndrome 1
BBS12 Bardet-Biedl syndrome 12
BBS2 Bardet-Biedl syndrome 2
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BRD2 bromodomain containing 2
BRS3 bombesin-like receptor 3
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C3AR1 complement component 3a receptor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL13 chemokine (C-C motif) ligand 13
CD36 CD36 molecule (thrombospondin receptor)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHRM3 cholinergic receptor, muscarinic 3
CIDEB cell death-inducing DFFA-like effector b
CIDEC cell death-inducing DFFA-like effector c
CLCN3 chloride channel, voltage-sensitive 3
CRBN cereblon
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSPG4 chondroitin sulfate proteoglycan 4
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DNM3OS DNM3 opposite strand/antisense RNA
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DRD2 dopamine receptor D2
DUSP1 dual specificity phosphatase 1
EDAR ectodysplasin A receptor
EIF3M eukaryotic translation initiation factor 3, subunit M
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4H eukaryotic translation initiation factor 4H
ESR1 estrogen receptor 1
ESRRA estrogen-related receptor alpha
FABP2 fatty acid binding protein 2, intestinal
FFAR3 free fatty acid receptor 3
FGF10 fibroblast growth factor 10
FGF21 fibroblast growth factor 21
FOXP2 forkhead box P2
FSHR follicle stimulating hormone receptor
FSTL3 follistatin-like 3 (secreted glycoprotein)
FTO fat mass and obesity associated
G0S2 G0/G1 switch 2
GCGR glucagon receptor
GDF15 growth differentiation factor 15
GFRA2 GDNF family receptor alpha 2
GHR growth hormone receptor
GNAS GNAS complex locus
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPR12 G protein-coupled receptor 12
HDC histidine decarboxylase
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HRC histidine rich calcium binding protein
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL18 interleukin 18
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
JUND jun D proto-oncogene
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KDM3A lysine (K)-specific demethylase 3A
KLF3 Kruppel-like factor 3 (basic)
KMT2B lysine (K)-specific methyltransferase 2B
LACTB2 lactamase, beta 2
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LGALS12 lectin, galactoside-binding, soluble, 12
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LHCGR luteinizing hormone/choriogonadotropin receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPE lipase, hormone-sensitive
LPIN1 lipin 1
LPL lipoprotein lipase
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPK8 mitogen-activated protein kinase 8
MBD5 methyl-CpG binding domain protein 5
MECP2 methyl CpG binding protein 2
MLXIPL MLX interacting protein-like
MMP19 matrix metallopeptidase 19
MPG N-methylpurine-DNA glycosylase
MSTN myostatin
NBEA neurobeachin
NCOA3 nuclear receptor coactivator 3
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC1 Niemann-Pick disease, type C1
NPR3 natriuretic peptide receptor 3
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NPY4R neuropeptide Y receptor Y4
NPY5R neuropeptide Y receptor Y5
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR2C2 nuclear receptor subfamily 2, group C, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OCA2 oculocutaneous albinism II
OMA1 OMA1 zinc metallopeptidase
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE10A phosphodiesterase 10A
PDE3B phosphodiesterase 3B, cGMP-inhibited
PGF placental growth factor
PHF2 PHD finger protein 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PITPNA phosphatidylinositol transfer protein, alpha
PLA2G1B phospholipase A2, group IB (pancreas)
PLIN1 perilipin 1
PLIN2 perilipin 2
PLSCR1 phospholipid scramblase 1
PLSCR3 phospholipid scramblase 3
PLVAP plasmalemma vesicle associated protein
PNPLA2 patatin-like phospholipase domain containing 2
PNRC2 proline-rich nuclear receptor coactivator 2
POMC proopiomelanocortin
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PRCP prolylcarboxypeptidase (angiotensinase C)
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRLR prolactin receptor
PROX1 prospero homeobox 1
PSIP1 PC4 and SFRS1 interacting protein 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTTG1 pituitary tumor-transforming 1
PYY peptide YY
RAI1 retinoic acid induced 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RBL1 retinoblastoma-like 1
RCAN2 regulator of calcineurin 2
RDH16 retinol dehydrogenase 16 (all-trans)
RLN3 relaxin 3
RMI1 RecQ mediated genome instability 1
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SELM selenoprotein M
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SGMS2 sphingomyelin synthase 2
SIK3 SIK family kinase 3
SIRT1 sirtuin 1
SIRT7 sirtuin 7
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC30A5 solute carrier family 30 (zinc transporter), member 5
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10
SOCS2 suppressor of cytokine signaling 2
SRA1 steroid receptor RNA activator 1
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TBC1D4 TBC1 domain family, member 4
TERF2IP telomeric repeat binding factor 2, interacting protein
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THRA thyroid hormone receptor, alpha
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TNF tumor necrosis factor
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TRIB1 tribbles pseudokinase 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSN translin
TWIST2 twist family bHLH transcription factor 2
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UNC5C unc-5 homolog C (C. elegans)
VGF VGF nerve growth factor inducible
VLDLR very low density lipoprotein receptor
WRN Werner syndrome, RecQ helicase-like
ZEB1 zinc finger E-box binding homeobox 1