abnormal excitatory postsynaptic potential Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization (Mammalian Phenotype Ontology, MP_0002912)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002912
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Genes

71 gene mutations causing the abnormal excitatory postsynaptic potential phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADORA1 adenosine A1 receptor
AFF2 AF4/FMR2 family, member 2
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
ASIC1 acid sensing (proton gated) ion channel 1
ATXN1 ataxin 1
BDNF brain-derived neurotrophic factor
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CD247 CD247 molecule
CD47 CD47 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CHRM1 cholinergic receptor, muscarinic 1
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHST10 carbohydrate sulfotransferase 10
CLCN3 chloride channel, voltage-sensitive 3
CLSTN3 calsyntenin 3
CNR1 cannabinoid receptor 1 (brain)
DLG2 discs, large homolog 2 (Drosophila)
DLGAP3 discs, large (Drosophila) homolog-associated protein 3
EFNA3 ephrin-A3
EGR3 early growth response 3
ESR2 estrogen receptor 2 (ER beta)
FYN FYN proto-oncogene, Src family tyrosine kinase
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GDI1 GDP dissociation inhibitor 1
GFAP glial fibrillary acidic protein
GJD2 gap junction protein, delta 2, 36kDa
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
GRIA2 glutamate receptor, ionotropic, AMPA 2
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIK2 glutamate receptor, ionotropic, kainate 2
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRM2 glutamate receptor, metabotropic 2
GRM5 glutamate receptor, metabotropic 5
GRN granulin
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KLK8 kallikrein-related peptidase 8
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRTM4 leucine rich repeat transmembrane neuronal 4
MAPK9 mitogen-activated protein kinase 9
NLGN3 neuroligin 3
NRGN neurogranin (protein kinase C substrate, RC3)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPHN1 oligophrenin 1
OPRM1 opioid receptor, mu 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
RARB retinoic acid receptor, beta
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RIMS1 regulating synaptic membrane exocytosis 1
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RUNX3 runt-related transcription factor 3
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SEZ6 seizure related 6 homolog (mouse)
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHANK3 SH3 and multiple ankyrin repeat domains 3
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10
SPRED1 sprouty-related, EVH1 domain containing 1
SST somatostatin
STX1A syntaxin 1A (brain)
STXBP5 syntaxin binding protein 5 (tomosyn)
SYN1 synapsin I
SYN2 synapsin II
SYNGAP1 synaptic Ras GTPase activating protein 1
TNIK TRAF2 and NCK interacting kinase
TRIB2 tribbles pseudokinase 2
WASF1 WAS protein family, member 1