abnormal eosinophil physiology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any functional anomaly of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin and is involved in clearance of parasitic infections and in allergic reactions (Mammalian Phenotype Ontology, MP_0002465)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002465
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Genes

26 gene mutations causing the abnormal eosinophil physiology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
C3AR1 complement component 3a receptor 1
CCL11 chemokine (C-C motif) ligand 11
CCR3 chemokine (C-C motif) receptor 3
CCR6 chemokine (C-C motif) receptor 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CXCR2 chemokine (C-X-C motif) receptor 2
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FYN FYN proto-oncogene, Src family tyrosine kinase
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
ICAM2 intercellular adhesion molecule 2
IL13 interleukin 13
IL1RL1 interleukin 1 receptor-like 1
IL21R interleukin 21 receptor
IL4 interleukin 4
INPP5D inositol polyphosphate-5-phosphatase, 145kDa
KDM6B lysine (K)-specific demethylase 6B
LTB4R leukotriene B4 receptor
PTGDR2 prostaglandin D2 receptor 2
S100A4 S100 calcium binding protein A4
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SIGLEC8 sialic acid binding Ig-like lectin 8
SPRED1 sprouty-related, EVH1 domain containing 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TPSAB1 tryptase alpha/beta 1
TRAF3IP2 TRAF3 interacting protein 2