abnormal dna repair Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the process of restoring DNA after damage or replication error (Mammalian Phenotype Ontology, MP_0008058)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008058
Similar Terms
Downloads & Tools


77 gene mutations causing the abnormal dna repair phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ALKBH2 alkB, alkylation repair homolog 2 (E. coli)
APLF aprataxin and PNKP like factor
APTX aprataxin
ARHGAP1 Rho GTPase activating protein 1
ATAD5 ATPase family, AAA domain containing 5
ATMIN ATM interactor
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
CDC14B cell division cycle 14B
CENPJ centromere protein J
CHD2 chromodomain helicase DNA binding protein 2
COPS5 COP9 signalosome subunit 5
CTC1 CTS telomere maintenance complex component 1
CUL4A cullin 4A
DKC1 dyskeratosis congenita 1, dyskerin
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC8 excision repair cross-complementation group 8
EXO1 exonuclease 1
FEN1 flap structure-specific endonuclease 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GGN gametogenetin
HORMAD1 HORMA domain containing 1
IP6K2 inositol hexakisphosphate kinase 2
IRF1 interferon regulatory factor 1
LIG4 ligase IV, DNA, ATP-dependent
M1AP meiosis 1 associated protein
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MCM8 minichromosome maintenance complex component 8
MDC1 mediator of DNA-damage checkpoint 1
MEIOB meiosis specific with OB domains
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MUS81 MUS81 structure-specific endonuclease subunit
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NHEJ1 nonhomologous end-joining factor 1
NTHL1 nth endonuclease III-like 1 (E. coli)
OGG1 8-oxoguanine DNA glycosylase
PARP1 poly (ADP-ribose) polymerase 1
PARP2 poly (ADP-ribose) polymerase 2
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
PNP purine nucleoside phosphorylase
POLB polymerase (DNA directed), beta
POLK polymerase (DNA directed) kappa
POLL polymerase (DNA directed), lambda
PRDM9 PR domain containing 9
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAD21L1 RAD21-like 1 (S. pombe)
RIF1 replication timing regulatory factor 1
SIRT1 sirtuin 1
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
SLX4 SLX4 structure-specific endonuclease subunit
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SOD2 superoxide dismutase 2, mitochondrial
SPATA22 spermatogenesis associated 22
SPO11 SPO11 meiotic protein covalently bound to DSB
STIP1 stress-induced phosphoprotein 1
SYCE1 synaptonemal complex central element protein 1
TDG thymine-DNA glycosylase
TDP1 tyrosyl-DNA phosphodiesterase 1
TDRKH tudor and KH domain containing
TERC telomerase RNA component
TET1 tet methylcytosine dioxygenase 1
TEX15 testis expressed 15
TP53BP1 tumor protein p53 binding protein 1
TRIP13 thyroid hormone receptor interactor 13
UBE2B ubiquitin-conjugating enzyme E2B
UIMC1 ubiquitin interaction motif containing 1
UNG uracil-DNA glycosylase
XPA xeroderma pigmentosum, complementation group A
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZC3HC1 zinc finger, C3HC-type containing 1